ArticleACS nano2015
Enhancing the imaging and biosafety of upconversion nanoparticles through phosphonate coating.
Article in ACS nano, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Exosome engineered upconversion nanoparticles with targeting moieties enhance Aβ aggregate clearance and mitigate neurotoxicity in Alzheimer's disease.Scientific reports · 2025Article
- Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis.Particle and fibre toxicology · 2025Article
- Impact of surface chemistry of upconversion nanoparticles on time-dependent cytotoxicity in non-cancerous epithelial cells.Scientific reports · 2024Article
- Multimodal Radiobioconjugates of Magnetic Nanoparticles Labeled withPharmaceutics · 2023Article
- Saturation magnetisation as an indicator of the disintegration of barium hexaferrite nanoplatelets during the surface functionalisation.Scientific reports · 2023Article
- Rose Bengal-Modified Upconverting Nanoparticles: Synthesis, Characterization, and Biological Evaluation.Life (Basel, Switzerland) · 2022Article
- CeONano today · 2022Article
- Understanding Nanomaterial-Liver Interactions to Facilitate the Development of Safer Nanoapplications.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- PEG-Neridronate-Modified NaYFACS omega · 2021Article
- Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells.Beilstein journal of nanotechnology · 2021Article
- Assessing the protective effects of different surface coatings on NaYFScientific reports · 2020Article
- Formation of Fe(III)-phosphonate Coatings on Barium Hexaferrite Nanoplatelets for Porous Nanomagnets.ACS omega · 2020Article
- Continued Efforts on Nanomaterial-Environmental Health and Safety Is Critical to Maintain Sustainable Growth of Nanoindustry.Small (Weinheim an der Bergstrasse, Germany) · 2020Review
- Mechanistic Differences in Cell Death Responses to Metal-Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes.Small (Weinheim an der Bergstrasse, Germany) · 2020Article
- Optically Robust and Biocompatible Mechanosensitive Upconverting Nanoparticles.ACS central science · 2019Article
- Article
- The Bioavailability, Biodistribution, and Toxic Effects of Silica-Coated Upconversion NanoparticlesFrontiers in chemistry · 2019Article
- Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores.Beilstein journal of nanotechnology · 2019Article
- Current approaches for safer design of engineered nanomaterials.Ecotoxicology and environmental safety · 2018Review
- Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces.Nature communications · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Upconversion nanoparticles (UCNPs), which are generated by doping with rare earth (RE) metals, are increasingly used for bioimaging because of the advantages they hold over conventional fluorophores. However, because pristine RE nanoparticles (NPs) are unstable in acidic physiological fluids (e.g., lysosomes), leading to intracellular phosphate complexation with the possibility of lysosomal injury, it is important to ensure that UCNPs are safely designed. In this study, we used commercially available NaYF4:Er/Yb UCNPs to study their stability in lysosomes and simulated lysosomal fluid. We demonstrate that phosphate complexation leads to REPO4 deposition on the particle surfaces and morphological transformation. This leads to a decline in upconversion fluorescence efficiency as well as inducing pro-inflammatory effects at the cellular level and in the intact lung. In order to preserve the imaging properties of the UCNPs as well as improve their safety, we experimented with a series of phosphonate chemical moieties to passivate particle surfaces through the strong coordination of the organophosphates with RE atoms. Particle screening and physicochemical characterization revealed that ethylenediamine tetra(methylenephosphonic acid) (EDTMP) surface coating provides the most stable UCNPs, which maintain their imaging intensity and do not induce pro-inflammatory effects in vitro and in vivo. In summary, phosphonate coating presents a safer design method that preserves and improves the bioimaging properties of UCNPs, thereby enhancing their biological use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.