Evidence map›Paper›PMID 25727384›Full record

ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2015

Cardiorenal Syndrome and the Role of the Bone-Mineral Axis and Anemia.

David M Charytan, Steven Fishbane, Jolanta Malyszko, Peter A McCullough, David Goldsmith

Abstract readReview
In one paragraph

Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Anemia of cardiorenal syndrome.Kidney international supplements · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David M CharytanRenal Division, Brigham and Women's Hospital, Boston, MA. Electronic address: dcharytan@partners.org.
Steven FishbaneDivision of Kidney Diseases and Hypertension, North Shore University Hospital and Long Island Jewish Medical Center, Great Neck, NY.
Jolanta Malyszko2nd Department of Nephrology, Medical University, Bialystok, Poland.
Peter A McCulloughBaylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas; The Heart Hospital, Plano, TX.
David GoldsmithDepartment of Nephrology, King's Health Partners Academic Health Sciences Centre, London, United Kingdom.

Funding

Aldosterone, nitric oxide, myocardial fibrosis, and capillary loss in ESRDU01DK096189 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI MCCAUSLAND, FINNIAN R · 2013 to 2017
$2.4M
Optimizing Revascularization of Coronary Artery Disease in Chronic Kidney DiseaseR01HL118314 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHARYTAN, DAVID M · 2014 to 2017
$1.7M
NO, myocardial fibrosis, and microvascular rarefaction in ESRD: Pilot StudiesR21DK100772 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI CHARYTAN, DAVID M · 2014 to 2015
$486k
NHLBI NIH HHS R01 HL118314NIDDK NIH HHS R21 DK100772NIDDK NIH HHS U01 DK096189
6 · The paper itself

Abstract

The association between chronic kidney disease (CKD) and cardiovascular disease (CVD) is well established, and there is mounting evidence of interorgan cross talk that may accelerate pathologic processes and the progression of organ dysfunction in both systems. This process, termed cardiorenal syndrome (CRS) by the Acute Dialysis Quality Initiative, is considered a major health problem: patients with CKD and CVD are at much higher risk of mortality than patients with either condition alone. To date, the majority of CRS research has focused on neurohormonal mechanisms and hemodynamic alterations. However, mounting evidence suggests that abnormalities in the normal pathophysiology of the bone-mineral axis, iron, and erythropoietin play a role in accelerating CKD and CVD. The goal of this article is to review the role and interrelated effects of the bone-mineral axis and anemia in the pathogenesis of chronic CRS.

Indexed as

AnemiaBone and BonesCalcifediolCalcitriolCalciumCardio-Renal SyndromeCardiovascular DiseasesErythropoietinFibroblast Growth Factor-23Fibroblast Growth FactorsHumansIronParathyroid HormonePhosphatesRenal Insufficiency, ChronicCalcifediolCalcitriolCalciumErythropoietinFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsIronParathyroid HormonePhosphatesanemiabone-mineral axisCardiorenal syndrome (CRS)cardiovascular disease (CVD)chronic kidney disease (CKD)end-stage renal disease (ESRD)erythropoietin (EPO)fibroblast growth factor 23 (FGF-23)heart failure (HF)ironphosphaterenal dysfunctionreviewvitamin D

Identifiers

PMID25727384
PMCPMC4516683

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.