ArticleMolecular plant pathology2015
Degradation of the benzoxazolinone class of phytoalexins is important for virulence of Fusarium pseudograminearum towards wheat.
Article in Molecular plant pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Bacterial degradation of a plant toxin and nutrient competition with commensals trade off to constrain pathogen growth.mSystems · 2026Article
- Effector FpECIR from Fusarium pseudograminearum targets wheat ethylene signaling pathway to suppress plant immunity.Stress biology · 2026Article
- Crown rot in wheat: pathogen biology, host responses, and management strategies.Stress biology · 2025Review
- Research progress on the analysis of resistance genes and mechanisms of wheat fusarium crown rot.Frontiers in plant science · 2025Review
- The lactonase BxdA mediates metabolic specialisation of maize root bacteria to benzoxazinoids.Nature communications · 2024Article
- The Phosphatase Cascade Nem1/Spo7-Pah1 Regulates Fungal Development, Lipid Homeostasis, and Virulence in Botryosphaeria dothidea.Microbiology spectrum · 2023Article
- Combined effects of host genetics and diet on porcine intestinal fungi and their pathogenic genes.Frontiers in microbiology · 2023Article
- The Drug HJournal of fungi (Basel, Switzerland) · 2022Article
- Analysis of the chromosomal clustering of Fusarium-responsive wheat genes uncovers new players in the defence against head blight disease.Scientific reports · 2021Article
- Disarming the Host: Detoxification of Plant Defense Compounds During Fungal Necrotrophy.Frontiers in plant science · 2021Review
- TheFrontiers in genetics · 2020Article
- The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog.World journal of microbiology & biotechnology · 2019Article
- Resolution of quantitative resistance to clubroot into QTL-specific metabolic modules.Journal of experimental botany · 2019Article
- A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum.Nature communications · 2019Article
- Deletion of the benzoxazinoid detoxification gene NAT1 in Fusarium graminearum reduces deoxynivalenol in spring wheat.PloS one · 2019Article
- Fusarium crown rot caused by Fusarium pseudograminearum in cereal crops: recent progress and future prospects.Molecular plant pathology · 2018Article
- Specialized plant biochemistry drives gene clustering in fungi.The ISME journal · 2018Article
- A high-resolution genetic map of the cereal crown rot pathogen Fusarium pseudograminearum provides a near-complete genome assembly.Molecular plant pathology · 2018Article
- Transcriptome analysis of Brachypodium during fungal pathogen infection reveals both shared and distinct defense responses with wheat.Scientific reports · 2017Article
- The novel fungal-specific gene FUG1 has a role in pathogenicity and fumonisin biosynthesis in Fusarium verticillioides.Molecular plant pathology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wheat, maize, rye and certain other agriculturally important species in the Poaceae family produce the benzoxazolinone class of phytoalexins on pest and pathogen attack. Benzoxazolinones can inhibit the growth of pathogens. However, certain fungi can actively detoxify these compounds. Despite this, a clear link between the ability to detoxify benzoxazolinones and pathogen virulence has not been shown. Here, through comparative genome analysis of several Fusarium species, we have identified a conserved genomic region around the FDB2 gene encoding an N-malonyltransferase enzyme known to be involved in benzoxazolinone degradation in the maize pathogen Fusarium verticillioides. Expression analyses demonstrated that a cluster of nine genes was responsive to exogenous benzoxazolinone in the important wheat pathogen Fusarium pseudograminearum. The analysis of independent F. pseudograminearum FDB2 knockouts and complementation of the knockout with FDB2 homologues from F. graminearum and F. verticillioides confirmed that the N-malonyltransferase enzyme encoded by this gene is central to the detoxification of benzoxazolinones, and that Fdb2 contributes quantitatively to virulence towards wheat in head blight inoculation assays. This contrasts with previous observations in F. verticillioides, where no effect of FDB2 mutations on pathogen virulence towards maize was observed. Overall, our results demonstrate that the detoxification of benzoxazolinones is a strategy adopted by wheat-infecting F. pseudograminearum to overcome host-derived chemical defences.
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