Evidence map›Paper›PMID 25727290›Full record

ReviewAdvances in immunology2015

Innate memory T cells.

Stephen C Jameson, You Jeong Lee, Kristin A Hogquist

Abstract readReview
In one paragraph

Review in Advances in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

  1. Article
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  11. The dynamics and longevity of circulating CD4bioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Review
  16. Review
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  19. Article
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephen C JamesonCenter for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. Electronic address: james024@umn.edu.
You Jeong LeeCenter for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Kristin A HogquistCenter for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. Electronic address: hogqu001@umn.edu.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUELLER, DANIEL L · 1993 to 2023
$31.1M
Peptide induction of positive selectionR01AI039560 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HOGQUIST, KRISTIN A. · 2001 to 2010
$3.1M
NCI NIH HHS P30 CA077598NIAID NIH HHS P01 AI035296NIAID NIH HHS R01 AI039560
6 · The paper itself

Abstract

Memory T cells are usually considered to be a feature of a successful immune response against a foreign antigen, and such cells can mediate potent immunity. However, in mice, alternative pathways have been described, through which naïve T cells can acquire the characteristics and functions of memory T cells without encountering specific foreign antigen or the typical signals required for conventional T cell differentiation. Such cells reflect a response to the internal rather the external environment, and hence such cells are called innate memory T cells. In this review, we describe how innate memory subsets were identified, the signals that induce their generation and their functional properties and potential role in the normal immune response. The existence of innate memory T cells in mice raises questions about whether parallel populations exist in humans, and we discuss the evidence for such populations during human T cell development and differentiation.

Indexed as

Immunity, InnateImmunologic MemoryAnimalsCD8-Positive T-LymphocytesCell DifferentiationCytokinesHomeostasisHumansLymphocyte ActivationLymphopeniaMiceNatural Killer T-CellsT-Lymphocyte SubsetsCytokinesCD8 T cellsCytokinesHomeostasisImmune memoryNKT cells

Identifiers

PMID25727290
PMCPMC4670568

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.