ReviewBiological psychiatry2015
Diagnostic Biomarkers for Posttraumatic Stress Disorder: Promising Horizons from Translational Neuroscience Research.
Review in Biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04592770 (Effect of Nature-based Exercise on Post-traumatic Growth Among People With Post-traumatic Stress), which is not on this map. Cited by 104 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Nature-based Exercise on Post-traumatic Growth Among People With Post-traumatic Stress: A Randomized Placebo-controlled Trial Designed to Observe Psychophysiological Alterations Before to After Intervention
Who cites it
104 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Prospective biomarkers of posttraumatic stress disorder in children and adolescents: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- An Overview of Stress Analysis Based on Physiological Signals: Systematic Review of Open Datasets and Current Trends.Sensors (Basel, Switzerland) · 2025Pooled it
- Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study.BMC psychiatry · 2025Pooled it
- PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Pooled it
- Cortisol, heart rate, and blood pressure as early markers of PTSD risk: A systematic review and meta-analysis.Clinical psychology review · 2016Pooled it
- A systematic review of the neural bases of psychotherapy for anxiety and related disorders.Dialogues in clinical neuroscience · 2015Pooled it
- From Biomarkers to New Treatments for Post-Traumatic Stress Disorder.Neuroscience bulletin · 2026Review
- Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank.Molecular psychiatry · 2026Article
- The effect of tert-butylhydroquinone on anxiolytic- and antidepressant-like behaviors induced by post-traumatic stress disorder: A behavioral and molecular study.Iranian journal of basic medical sciences · 2026Article
- Neuroimmune Interactions in Stress and Depression: Exploring the Molecular and Cellular Mechanisms within the Neuroinflammation-depression Nexus.Current medicinal chemistry · 2026Review
- Applying the Research Domain Criteria to Social Determinants of Community Mental Health in Low-Resource Settings: A Contextualized Framework with Insights from the TOPOWA Study.Community mental health journal · 2026Article
- Effectiveness of a Mind-Body Intervention at Improving Mental Health and Performance Among Career Firefighters.International journal of environmental research and public health · 2025Article
- Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Trauma and Sensory Systems: Biological Mechanisms Involving the Skin and the 17q21 Gene Cluster.Biological psychiatry · 2025Review
- Assessment of PTSD in military personnel via machine learning based on physiological habituation in a virtual immersive environment.Scientific reports · 2025Article
- Circulating biomarkers and neuroanatomical brain structures differ in older adults with and without post-traumatic stress disorder.Scientific reports · 2025Article
- Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.Nature. Mental health · 2025Article
- A systematic review of machine learning findings in PTSD and their relationships with theoretical models.Nature. Mental health · 2025Article
- Role of LncRNA in Trauma Susceptibility and Resilience to Post-Traumatic Stress Disorder (PTSD): A Pilot Study in the African American Population.Neuropsychiatric disease and treatment · 2025Article
- Shared genetic risk and causal associations between Post-traumatic stress disorder and migraine with antithrombotic agents and other medications.Neurobiology of stress · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is a heterogeneous disorder that affects individuals exposed to trauma (e.g., combat, interpersonal violence, and natural disasters). Although its diagnostic features have been recently reclassified with the emergence of the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition, the disorder remains characterized by hyperarousal, intrusive reminders of the trauma, avoidance of trauma-related cues, and negative cognition and mood. This heterogeneity indicates the presence of multiple neurobiological mechanisms underlying the etiology and maintenance of PTSD. Translational research spanning the past few decades has revealed several potential avenues for the identification of diagnostic biomarkers for PTSD. These include, but are not limited to, monoaminergic transmitter systems, the hypothalamic-pituitary-adrenal axis, metabolic hormonal pathways, inflammatory mechanisms, psychophysiological reactivity, and neural circuits. The current review provides an update to the literature with regard to the most promising putative PTSD biomarkers, with specific emphasis on the interaction between neurobiological influences on disease risk and symptom progression. Such biomarkers will most likely be identified by multi-dimensional models derived from comprehensive descriptions of molecular, neurobiological, behavioral, and clinical phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.