Evidence map›Paper›PMID 25727099›Full record

ArticleCell proliferation2015

Prognostic value of circulating CD133(+) cells in patients with gastric cancer.

Pu Xia, Chang-Liang Song, Jin-Fang Liu, Dan Wang, Xiao-Yan Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Pu XiaDepartment of Cell Biology, Basic Medical College of Liaoning Medical University, Jinzhou, Liaoning, 121000, China.
Chang-Liang Song
Jin-Fang Liu
Dan Wang
Xiao-Yan Xu
China Medical University · CNJinzhou Medical University · CNHandan College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesGastric cancer is an important cause of cancer-related mortality worldwide (1). There is increasing evidence that the existence of cancer stem cells (CSC) is responsible for tumour formation and maintenance. MATERIALS AND

methodsThe present study was designed to recognise circulating CSCs from blood samples of patients with gastric cancer, using CD133 and ABCG2 as potential markers. CD133(-) , CD133(+)  ABCG2(-) and CD133(+)  ABCG2(+) cells lines were analysed by flow cytometry, immunofluorescence staining, western blotting and real-time PCR. Furthermore, functional assays (clonogenic assay in vitro and tumourigenic assay in vivo) were also performed using these cell lines.

resultsHigher percentages of CD133(+) cells were identified in blood samples from gastric cancer patients compared to normal controls. In addition, we found by using Kaplan-Meier analysis, that numbers of CD133(+) cells correlated with poor prognosis gastric cancer patients. Finally, tumourigenic properties of CD133(+)  ABCG2(+) cells were determined in vitro and in vivo.

conclusionsOur in vitro and in vivo experiments demonstrated that CD133(+)  ABCG2(+) cells exhibited well-known CSC characteristics; thus when circulating they could be used as a prognostic marker for gastric cancer.

Indexed as

AC133 AntigenAgedAntigens, CDATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2Biomarkers, TumorCarcinogenesisClone CellsFemaleGene ExpressionGlycoproteinsHumansLymphatic MetastasisMaleMiddle AgedNeoplasm ProteinsABCG2 protein, humanAC133 AntigenAntigens, CDATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2Biomarkers, TumorGlycoproteinsNeoplasm ProteinsPeptidesPROM1 protein, human

Identifiers

PMID25727099
PMCPMC6496317
OpenAlexW2006464504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.