Evidence map›Paper›PMID 25726820›Full record

ArticleRevista de neurologia2015

Reducing age of autism diagnosis: developmental social neuroscience meets public health challenge.

Ami Klin, Cheryl Klaiman, Warren Jones

Open access · greenAbstract read
In one paragraph

Article in Revista de neurologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Comparative Analysis of Autistic Women Across the Lifespan: Childhood vs. Adulthood Diagnosis.Autism research : official journal of the International Society for Autism Research · 2025
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  11. Prevalence and Risk-Markers of Self-Harm in Autistic Children and Adults.Journal of autism and developmental disorders · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ami KlinChildren's Healthcare of Atlanta and Emory University School of Medicine. Atlanta, Georgia, EE.UU.
Cheryl Klaiman
Warren Jones
Children's Healthcare of Atlanta · US

Funding

The ontogeny of social vocal engagement and its derailment in autismP50MH100029 · NIMH · EMORY UNIVERSITY · PI RAMSAY, GORDON JAMES · 2012 to 2021
$20.1M
The Ontogeny of Social Visual Engagement in Infants at Risk for AutismR01MH083727 · NIMH · YALE UNIVERSITY · PI JONES, WARREN · 2008 to 2012
$2.7M
NIMH NIH HHS P50 MH100029NIMH NIH HHS P50-MH100029NIMH NIH HHS R01 MH083727
6 · The paper itself

Abstract

Autism spectrum disorder (autism) is a highly prevalent and heterogeneous family of neurodevelopmental disorders of genetic origins with potentially devastating implications for child, family, health and educational systems. Despite advances in paper-and-pencil screening and in standardization of diagnostic procedures, diagnosis of autism in the US still hovers around the ages of four or five years, later still in disadvantaged communities, and several years after the age of two to three years when the condition can be reliably diagnosed by expert clinicians. As early detection and treatment are two of the most important factors optimizing outcome, and given that diagnosis is typically a necessary condition for families to have access to early treatment, reducing age of diagnosis has become one of the greatest priorities of the field. Recent advances in developmental social neuroscience promise the advent of cost-effective and community-viable, performance-based procedures, and suggest a complementary method for promoting universal screening and much greater access to the diagnosis process. Small but critical studies have already reported on experiments that differentiate groups of children at risk for autism from controls, and at least one study so far could predict diagnostic classification and level of disability on the basis of a brief experiment. Although the road to translating such procedures into effective devices for screening and diagnosis is still a long one, and premature claims should be avoided, this effort could be critical in addressing this worldwide public health challenge.

Indexed as

Age FactorsAutistic DisorderChild, PreschoolHumansInfantInterpersonal RelationsNeurosciencesPublic HealthSocial Change

Identifiers

PMID25726820
PMCPMC4399764
OpenAlexW103614987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.