Evidence map›Paper›PMID 25726568›Full record

SynthesisJournal of the American Medical Informatics Association : JAMIA2015

Technology-mediated interventions for enhancing medication adherence.

Niraj Mistry, Arun Keepanasseril, Nancy L Wilczynski, Robby Nieuwlaat, Manthan Ravall, R Brian Haynes, Patient Adherence Review Team

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Medical Informatics Association : JAMIA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. A systematic overview of systematic reviews evaluating medication adherence interventions.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Niraj MistryPediatric Outcomes Research Team (PORT), Division of Paediatric Medicine, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada Department of Pediatrics, St. Michael's Hospital, University of Toronto, Toronto, Canada niraj.mistry@mail.utoronto.ca.
Arun KeepanasserilDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton Canada Department of Medicine, McMaster University, Hamilton, Canada.
Nancy L WilczynskiHealth Information Research Unit, McMaster University, Hamilton, Canada.
Robby NieuwlaatDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton Canada.
Manthan RavallHealth Information Research Unit, McMaster University, Hamilton, Canada.
R Brian HaynesDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton Canada Department of Medicine, McMaster University, Hamilton, Canada.
Patient Adherence Review Team

Funding

Canadian Institutes of Health Research KRS 262115
6 · The paper itself

Abstract

backgroundDespite effective therapies for many conditions, patients find it difficult to adhere to prescribed treatments. Technology-mediated interventions (TMIs) are increasingly being used with the hope of improving adherence.

objectiveTo assess the effects of TMI, intended to enhance patient adherence to prescribed medications, on both medication adherence and clinical outcomes.

methodsA secondary in-depth analysis was conducted of the subset of studies that utilized technology in at least one component of the intervention from an updated Cochrane review on all interventions for enhancing medication adherence. We included studies that clearly described an information and communication technology or medical device as the sole or major component of the adherence intervention.

resultsThirty-eight studies were eligible for in-depth review. Only seven had a low risk of bias for study design features, primary adherence, and clinical outcomes. Eighteen studies used a TMI for education and/or counseling, 11 studies used a TMI for self-monitoring and/or feedback, and nine studies used electronic reminders. Studies used a variety of TMIs, with telephone the most common technology in use. Studies targeted a wide distribution of diseases and used a variety of adherence and clinical outcome measures. A minority targeted children and adolescents. Fourteen studies reported significant effects in both adherence and clinical outcome measures.

conclusionsThis review provides evidence for the inconsistent effectiveness of TMI for medication adherence and clinical outcomes. These results must be interpreted with caution due to a lack of high-quality studies.

Indexed as

Medication AdherenceReminder SystemsTelemedicineAdolescentAdultChild, PreschoolHumansInternetSelf AdministrationTelephoneeHealthoutcomespatient adherencereminder systemssystematic reviewtechnology mediation

Identifiers

PMID25726568
PMCPMC7659214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.