Evidence map›Paper›PMID 25726552›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2015

Advances in asthma pathophysiology: stepping forward from the Maurizio Vignola experience.

Maria R Bonsignore, Mirella Profita, Rosalia Gagliardo, Loredana Riccobono, Giuseppina Chiappara, Elisabetta Pace, Mark Gjomarkaj

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Airway Remodeling in Asthma.Frontiers in medicine · 2020
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria R BonsignoreBiomedical Dept of Internal and Specialistic Medicine (DiBiMIS), Pneumology, University of Palermo, Palermo, Italy Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy marisa@ibim.cnr.it.
Mirella ProfitaInstitute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Rosalia GagliardoInstitute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Loredana RiccobonoInstitute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Giuseppina ChiapparaInstitute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Elisabetta PaceInstitute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Mark GjomarkajInstitute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maurizio Vignola was a superb and innovative researcher, who wrote seminal papers on the biology of airway epithelium in asthma. Inflammation and remodelling were the main topics of his research, mostly conducted in biopsy specimens from patients with asthma of variable severity, encompassing the entire spectrum of the disease from mild to severe asthma. His observations contributed to define the biology of asthma as we know it today, and opened the way to the personalised treatment of asthma. His group has successfully continued to investigate the biology and clinical aspects of bronchial asthma, with major interest in the clinical use of biomarkers to monitor disease activity, and in the development of new therapeutic perspectives. This review summarises the latest work on these topics proudly conducted by Maurizio's closest collaborators. The results indicate significant progress in our understanding of asthma in the last 10 years, in particular increased knowledge of the complex interaction between inflammatory and remodelling pathways, improved recognition of biological and clinical asthma phenotypes, and development of new treatment strategies, especially for patients with severe corticosteroid-resistant asthma.

Indexed as

Adrenal Cortex HormonesAirway RemodelingAsthmaBiomarkersDrug ResistanceGlucocorticoidsHumansInflammationAdrenal Cortex HormonesBiomarkersGlucocorticoids

Identifiers

PMID25726552
PMCPMC9487772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.