Evidence map›Paper›PMID 25726158›Full record

ArticleClinical biomechanics (Bristol, Avon)2015

Individuals with isolated patellofemoral joint osteoarthritis exhibit higher mechanical loading at the knee during the second half of the stance phase.

Hsiang-Ling Teng, Toran D MacLeod, Deepak Kumar, Thomas M Link, Sharmila Majumdar, Richard B Souza

Abstract read
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In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hsiang-Ling TengDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. Electronic address: Hsiang-Ling.Teng@ucsf.edu.
Toran D MacLeodDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA; Department of Physical Therapy, California State University, Sacramento, CA, USA. Electronic address: toran.macleod@csus.edu.
Deepak KumarDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. Electronic address: deepak.kumar@ucsf.edu.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. Electronic address: Thomas.Link@ucsf.edu.
Sharmila MajumdarDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. Electronic address: Sharmila.Majumdar@ucsf.edu.
Richard B SouzaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA; Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, USA. Electronic address: Richard.Souza@ucsf.edu.

Funding

MRI TO STUDY CARTILAGE/BONE INTERACTIONSR01AR046905 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 1999 to 2015
$6.3M
Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2011 to 2015
$6.2M
Contact mechanics, neuromuscular control, and cartilage composition in knee OAR01AR062370 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2014
$1.1M
NIAMS NIH HHS P50 AR060752NIAMS NIH HHS R01 AR046905NIAMS NIH HHS R01 AR062370NIAMS NIH HHS R01AR062370
6 · The paper itself

Abstract

backgroundPatellofemoral joint osteoarthritis is a highly prevalent disease and an important source of pain and disability. Nonetheless, biomechanical risk factors associated with this disease remain unclear. The purpose of this study was to compare biomechanical factors that are associated with patellofemoral joint loading during walking between individuals with isolated patellofemoral joint osteoarthritis and no osteoarthritis.

methodsMR images of the knee were obtained using a 3D fast-spin echo sequence to identify patellofemoral joint cartilage lesions. Thirty-five subjects with isolated patellofemoral joint osteoarthritis (29 females) and 35 control subjects (21 females) walked at a self-selected speed and as fast as possible. Peak knee flexion moment, flexion moment impulse and peak patellofemoral joint stress during the first and second halves of the stance phase were compared between groups.

findingsWhen compared to the controls, individuals with patellofemoral joint osteoarthritis demonstrated significantly higher peak knee flexion moment (P=.03, Eta(2)=.07), higher knee flexion moment impulse (P=.03, Eta(2)=.07) and higher peak patellofemoral joint stress (P=.01, Eta(2)=.10) during the second half of the stance phase. No significant group difference was observed during the first half of the stance phase.

interpretationFindings of this study suggest that increased mechanical loading (i.e. knee flexion moment, impulse and patellofemoral joint stress) during the second half of the stance phase is associated with patellofemoral joint osteoarthritis. Prevention and rehabilitation programs for patellofemoral joint osteoarthritis may focus on reducing the loading on the patellofemoral joint, specifically during late stance.

Indexed as

AdultAnalysis of VarianceBiomechanical PhenomenaCase-Control StudiesFemaleGaitHumansMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneePatellofemoral JointStress, MechanicalWalkingGaitKineticsOsteoarthritisPatellofemoral jointStress

Identifiers

PMID25726158
PMCPMC4404202

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.