Evidence map›Paper›PMID 25725987›Full record

ArticleThe Journal of allergy and clinical immunology2015

Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma.

Sheena D Brown, Lou Ann Brown, Susan Stephenson, Jennifer C Dodds, Shaneka L Douglas, Hongyan Qu, Anne M Fitzpatrick

Abstract readLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. New Data on Anti-Inflammatory and Wound Healing Potential of TransgenicInternational journal of molecular sciences · 2023
    Article
  8. Observational
  9. Article
  10. Treating severe asthma: Targeting the IL-5 pathway.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Review
  11. Article
  12. Th1 cytokines TNF-α and IFN-γ promote corticosteroid resistance in developing human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2019
    Article
  13. Article
  14. Article
  15. BMJ open respiratory research · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sheena D BrownDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga.
Lou Ann BrownDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga; Children's Healthcare of Atlanta Center for Cystic Fibrosis and Airways Disease Research, Atlanta, Ga.
Susan StephensonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga.
Jennifer C DoddsDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga.
Shaneka L DouglasDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga.
Hongyan QuDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga.
Anne M FitzpatrickDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga; Children's Healthcare of Atlanta Center for Cystic Fibrosis and Airways Disease Research, Atlanta, Ga. Electronic address: anne.fitzpatrick@emory.edu.

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Redox disturbances and corticosteroid responses in children with severe asthmaR01NR012021 · NINR · EMORY UNIVERSITY · PI FITZPATRICK, ANNE MENTRO · 2010 to 2014
$1.9M
NCATS NIH HHS UL1 TR000454NINR NIH HHS R01 NR012021
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

PhenotypeAdolescentAnti-Inflammatory AgentsAsthmaCase-Control StudiesChildFemaleGene ExpressionHumansI-kappa B KinaseI-kappa B ProteinsMaleNF-kappa BNF-KappaB Inhibitor alphaNF-kappa B p50 SubunitPrecision MedicineAnti-Inflammatory AgentsCHUK protein, humanI-kappa B KinaseI-kappa B ProteinsIKBKB protein, humanNF-kappa BNF-KappaB Inhibitor alphaNF-kappa B p50 SubunitNFKB1 protein, humanNFKBIA protein, humanTriamcinoloneTumor Necrosis Factor-alpha

Identifiers

PMID25725987
PMCPMC4461527

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.