ArticleDrug and alcohol dependence2015
Effect of oral THC pretreatment on marijuana cue-induced responses in cannabis dependent volunteers.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications.BMC medicine · 2022Pooled it
- Artificial Intelligence Approximates Human Affect Ratings of Cannabis Images.medRxiv : the preprint server for health sciences · 2025Article
- Decreased incubation of fentanyl seeking in the absence of proximal drug-paired stimuli.Experimental and clinical psychopharmacology · 2025Article
- The role of sex in the association between cannabis use disorder and resting-state functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- A Secondary Analysis Suggests That Repetitive Transcranial Magnetic Stimulation Applied to the Left Dorsolateral Prefrontal Cortex Reduces Cue-Induced-Craving in Treatment Seeking Participants with Cannabis Use Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Sex differences in the subjective and reinforcing effects of smoked cannabis.Addiction biology · 2023Article
- The importance of psychology for shaping legal cannabis regulation.Experimental and clinical psychopharmacology · 2021Review
- Are There Therapeutic Benefits of Cannabinoid Products in Adult Mental Illness?Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Article
- Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Mechanisms Underlying Sex Differences in Cannabis Use.Current addiction reports · 2017Article
- Cue-elicited increases in incentive salience for marijuana: Craving, demand, and attentional bias.Drug and alcohol dependence · 2016Article
- Magnitude and duration of cue-induced craving for marijuana in volunteers with cannabis use disorder.Drug and alcohol dependence · 2016Article
- Sex differences in cannabinoid-regulated biology: A focus on energy homeostasis.Frontiers in neuroendocrinology · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe current study tested whether oral Δ(9)-tetrahydrocannabinol (THC: 0-, 10-, and 20-mg) pretreatment would attenuate polysensory cue-induced craving for marijuana.
methodsCannabis dependent participants (7 males and 7 females, who smoked on average 5.4 ± 1.1 blunts daily) completed 3 experimental sessions (oral THC pretreatment dose; counterbalanced order) using a placebo-controlled within-subject crossover design. During each session, participants completed a baseline evaluation and were first exposed to neutral cues then marijuana cues while physiological measures and subjective ratings of mood, craving, and drug effect were recorded.
resultsFollowing placebo oral THC pretreatment, marijuana (vs. neutral) cues significantly increased ratings of marijuana craving (desire and urge to use, Marijuana Craving Questionnaire (MCQ)-Compulsivity scale), anxious mood and feeling hungry. Males also reported feeling more "Down" during marijuana cues relative to females. Pretreatment with oral THC (10-mg and/or 20-mg vs. placebo) significantly attenuated marijuana cue-induced increases in craving and anxiety but not hunger. Oral THC attenuation of the cue-induced increase in MCQ-Compulsivity ratings was observed in females only. Oral THC produced statistically (but not clinically) significant increases in heart rate and decreases in diastolic blood pressure, independent of cues.
conclusionsThese marijuana-cue findings replicate earlier results and further demonstrate that oral THC can attenuate selected effects during marijuana multi-cue exposure, and that some of these effects may be sex-related. Results of this study suggest oral THC may be effective for reducing marijuana cue-elicited (conditioned) effects. Further study is needed to determine whether females may selectively benefit from oral THC for this purpose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.