ArticleClinical research in cardiology : official journal of the German Cardiac Society2015
High prevalence of peripheral arterial disease in patients with obstructive sleep apnoea.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of chronic carotid baroreceptor activation on arterial stiffness in severe heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Trial
- Hypoxia-Induced Insulin Resistance Mediates the Elevated Cardiovascular Risk in Patients with Obstructive Sleep Apnea: A Comprehensive Review.Reviews in cardiovascular medicine · 2024Review
- Relationship Between Peripheral Arterial Diseases and Obstructive Sleep Apnea: A Systematic Review.Cureus · 2023Review
- Advances in the study of OSA and diabetic foot.Diabetology & metabolic syndrome · 2022Review
- Association of sleep-disordered breathing and wound healing in patients with diabetic foot ulcers.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment.Frontiers in cardiovascular medicine · 2021Review
- Diagnostic Accuracy of Oxygen Desaturation Index for Sleep-Disordered Breathing in Patients With Diabetes.Frontiers in endocrinology · 2021Article
- Obstructive sleep apnea and peripheral vascular disease: a systematic review based on current literature.Journal of community hospital internal medicine perspectives · 2020Review
- Associations between ankle-brachial index, diabetes, and sleep apnea in the Hispanic community health study/study of Latinos (HCHS/SOL) database.BMC cardiovascular disorders · 2020Article
- Pathologic and hemodynamic changes of common carotid artery in obstructive sleep apnea hypopnea syndrome in a porcine modelTurkish journal of medical sciences · 2019Article
- CHADS₂, CHA₂DS₂ASc, and New ABCD Scores Predict the Risk of Peripheral Arterial Disease in Patients with Sleep Apnea.Journal of clinical medicine · 2019Article
- Effects of 12 weeks of regular aerobic exercises on autonomic nervous system in obstructive sleep apnea syndrome patients.Sleep & breathing = Schlaf & Atmung · 2018Article
- Carotid strain measurement in patients with pseudoxanthoma elasticum - Hint for a different pathomechanism?Intractable & rare diseases research · 2018Article
- Article
- Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study.Frontiers in physiology · 2018Article
- Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis?Sleep & breathing = Schlaf & Atmung · 2017Article
- High prevalence of COPD in atherosclerosis patients.International journal of chronic obstructive pulmonary disease · 2017Article
- Article
- Association of sleep apnea and sleep duration with peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis (MESA).Atherosclerosis · 2016Article
- Cardioversion of atrial fibrillation or atrial flutter into sinus rhythm reduces nocturnal central respiratory events and unmasks obstructive sleep apnoea.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Observational
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionObstructive sleep apnoea (OSA) merits increasing attention as cardiovascular risk factor. Whereas carotid and coronary artery disease have been associated with OSA, occurrence of peripheral arterial disease (PAD) in OSA remains undefined.
methodsWe screened 100 patients with suspected OSA for PAD. After polysomnography, each patient underwent standardized angiological testing including ankle-brachial index (ABI), central pulse wave velocity, pulse wave index and duplex sonography.
resultsAmong total study population, PAD prevalence accounted for 88%, of those 68% had asymptomatic plaques and 20% were symptomatic Fontaine ≥ IIa. In confirmed OSA, prevalence raised up to 98%. Except for smoking habits, distribution of established risk factors did not differ between OSA groups (patients without, mild, intermediate and severe OSA). Presence of plaque, Fontaine PAD stages and intermittent claudication exhibited significant gain with increasing AHI. A logistic regression model revealed that age (OR = 1.199, 95% CI [1.066; 1.348]) and the logarithmically transformed AHI (OR = 5.426, 95% CI [1.068; 27.567]) had the strongest influence on plaque presence. Central pulse wave velocity as marker of arterial stiffness was positively correlated with AHI.
conclusionOSA is associated with a high prevalence of PAD. This implies substantial diseasés under-recognition and a presumable atherogenic role of OSA in the pathogenesis of PAD. However, vasoprotective impact of OSA treatment remains to be determined.
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