ArticleBiomaterials2015
Development of a biological scaffold engineered using the extracellular matrix secreted by skeletal muscle cells.
Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Incorporating exosomes in tissue engineering scaffolds: pave the way toward clinical application.Annals of medicine and surgery (2012) · 2026Review
- Integrating Physical and Biochemical Cues for Muscle Engineering: Scaffolds and Graft Durability.Bioengineering (Basel, Switzerland) · 2024Review
- Three-Dimensional Microfibrous Scaffold with Aligned Topography Produced via a Combination of Melt-Extrusion Additive Manufacturing and Porogen Leaching for In Vitro Skeletal Muscle Modeling.Bioengineering (Basel, Switzerland) · 2024Article
- Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury.Scientific reports · 2023Article
- Extracellular Matrix Secretion Mechanically Reinforces Interlocking Interfaces.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Microfabricated Gaps Reveal the Effect of Geometrical Control in Wound Healing.Advanced healthcare materials · 2021Article
- In vivo testing of an injectable matrix gel for the treatment of shoulder cuff muscle fatty degeneration.Journal of shoulder and elbow surgery · 2020Article
- Article
- In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration.Nature communications · 2019Article
- Repeated In Vitro Impact Conditioning of Astrocytes Decreases the Expression and Accumulation of Extracellular Matrix.Annals of biomedical engineering · 2019Article
- Inhibition of osteoclastogenesis by stem cell-derived extracellular matrix through modulation of intracellular reactive oxygen species.Acta biomaterialia · 2018Article
- Cell derived extracellular matrix fibers synthesized using sacrificial hollow fiber membranes.Biomedical materials (Bristol, England) · 2017Article
- Codelivery of Infusion Decellularized Skeletal Muscle with Minced Muscle Autografts Improved Recovery from Volumetric Muscle Loss Injury in a Rat Model.Tissue engineering. Part A · 2016Article
- Recovery from volumetric muscle loss injury: A comparison between young and aged rats.Experimental gerontology · 2016Article
- The characterization of decellularized human skeletal muscle as a blueprint for mimetic scaffolds.Journal of materials science. Materials in medicine · 2016Article
- Matrix scaffolding for stem cell guidance toward skeletal muscle tissue engineering.Journal of orthopaedic surgery and research · 2016Review
- Biomimetic scaffolds for regeneration of volumetric muscle loss in skeletal muscle injuries.Acta biomaterialia · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The performance of implantable biomaterials derived from decellularized tissue, including encouraging results with skeletal muscle, suggests that the extracellular matrix (ECM) derived from native tissue has promising regenerative potential. Yet, the supply of biomaterials derived from donated tissue will always be limited, which is why the in-vitro fabrication of ECM biomaterials that mimic the properties of tissue is an attractive alternative. Towards this end, our group has utilized a novel method to collect the ECM that skeletal muscle myoblasts secrete and form it into implantable scaffolds. The cell derived ECM contained several matrix constituents, including collagen and fibronectin that were also identified within skeletal muscle samples. The ECM was organized into a porous network that could be formed with the elongated and aligned architecture observed within muscle samples. The ECM material supported the attachment and in-vitro proliferation of cells, suggesting effectiveness for cell transplantation, and was well tolerated by the host when examined in-vivo. The results suggest that the ECM collection approach can be used to produce biomaterials with compositions and structures that are similar to muscle samples, and while the physical properties may not yet match muscle values, the in-vitro and in-vivo results indicate it may be a suitable first generation alternative to tissue derived biomaterials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.