Evidence map›Paper›PMID 25725483›Full record

ArticleBiochimica et biophysica acta2015

Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer.

Imran Hussain, Arunoday Bhan, Khairul I Ansari, Paromita Deb, Samara A M Bobzean, Linda I Perrotti, Subhrangsu S Mandal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Embryonic Programs in Cancer and Metastasis-Insights From the Mammary Gland.Frontiers in cell and developmental biology · 2022
    Review
  9. Review
  10. Article
  11. Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.International journal of molecular sciences · 2020
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. PeerJ · 2019
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Imran HussainDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
Arunoday BhanDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
Khairul I AnsariDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
Paromita DebDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA.
Samara A M BobzeanDepartment of Psychology, The University of Texas at Arlington, Arlington, TX 76019, USA.
Linda I PerrottiDepartment of Psychology, The University of Texas at Arlington, Arlington, TX 76019, USA.
Subhrangsu S MandalDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, USA. Electronic address: smandal@uta.edu.
The University of Texas at Arlington · US

Funding

Endocrine Disruptors: Assessment of endocrine disruption activity, mechanism andR15ES019129 · NIEHS · UNIVERSITY OF TEXAS ARLINGTON · PI MANDAL, SUBHRANGSU S · 2010 to 2010
$445k
NIEHS NIH HHS 1R15 ES019129-01NIEHS NIH HHS R15 ES019129
6 · The paper itself

Abstract

HOXC6 is a homeobox-containing gene associated with mammary gland development and is overexpressed in variety of cancers including breast and prostate cancers. Here, we have examined the expression of HOXC6 in breast cancer tissue, investigated its transcriptional regulation via estradiol (E2) and bisphenol-A (BPA, an estrogenic endocrine disruptor) in vitro and in vivo. We observed that HOXC6 is differentially over-expressed in breast cancer tissue. E2 induces HOXC6 expression in cultured breast cancer cells and in mammary glands of Sprague Dawley rats. HOXC6 expression is also induced upon exposure to BPA both in vitro and in vivo. Estrogen-receptor-alpha (ERα) and ER-coregulators such as MLL-histone methylases are bound to the HOXC6 promoter upon exposure to E2 or BPA and that resulted in increased histone H3K4-trimethylation, histone acetylation, and recruitment of RNA polymerase II at the HOXC6 promoter. HOXC6 overexpression induces expression of tumor growth factors and facilitates growth 3D-colony formation, indicating its potential roles in tumor growth. Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo.

Indexed as

EpigenomicsAnimalsBenzhydryl CompoundsBisphenol A CompoundsBreast NeoplasmsEndocrine DisruptorsEstradiolEstrogen Receptor alphaEstrogensFemaleGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansMCF-7 CellsPhenolsRatsBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsESR1 protein, humanEstradiolEstrogen Receptor alphaEstrogensHomeodomain ProteinsHOXC6 protein, humanPhenolsBisphenol AEndocrine disruptionEpigeneticsEstrogen-receptorsHOXC6 expressionMixed lineage leukemia (MLL)

Identifiers

PMID25725483
PMCPMC4437882
OpenAlexW1987405718

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.