Trial reportHormones and behavior2015
Loneliness predicts postprandial ghrelin and hunger in women.
Trial report in Hormones and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Sex hormones, the gut microbiome, and neurodegenerative diseases: Lifespan perspective.Neural regeneration research · 2026Article
- Does Loneliness Hurt? Effect of Loneliness on Inflammator Biomarkers, Appetite Hormone Regulation, and Cognitive Function Among Typically Developing Adolescents.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2025Article
- Global Trends and Research Hotspots in Social Isolation Among Cancer Patients: A Bibliometric Analysis (2005-2024).Journal of multidisciplinary healthcare · 2025Review
- Is age more than a number? Accounting for adult development and aging in the study of psychoneuroimmunology, stress, and health.Comprehensive psychoneuroendocrinology · 2024Article
- Psychoneuroimmunology and the research of Janice Kiecolt-Glaser: It informs self-care and the practice of medicine.Comprehensive psychoneuroendocrinology · 2024Review
- Moving toward affective immunology: Legacy and future directions.Comprehensive psychoneuroendocrinology · 2024Article
- Hungry for compliments? Ghrelin is not associated with neural responses to social rewards or their pleasantness.Frontiers in psychiatry · 2023Article
- Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders.Current research in pharmacology and drug discovery · 2022Review
- Social Isolation and Loneliness During the COVID-19 Pandemic: Impact on Weight.Current obesity reports · 2021Review
- Measurement of the influences of social processes in appetite using ecological momentary assessment.Appetite · 2021Article
- Are the Self-esteem, Self-efficacy, and Interpersonal Interaction of Junior College Students Related to the Solitude Capacity?International journal of environmental research and public health · 2020Article
- COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.Cardiovascular research · 2020Article
- Threats to Belonging, Immune Function, and Eating Behavior: an Examination of Sex and Gender Differences.Current psychiatry reports · 2018Review
- Loneliness is adversely associated with physical and mental health and lifestyle factors: Results from a Swiss national survey.PloS one · 2017Article
- Sugarcoated isolation: evidence that social avoidance is linked to higher basal glucose levels and higher consumption of glucose.Frontiers in psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Loneliness is strongly linked to poor health. Recent research suggests that appetite dysregulation provides one potential pathway through which loneliness and other forms of social disconnection influence health. Obesity may alter the link between loneliness and appetite-relevant hormones, one unexplored possibility. We examined the relationships between loneliness and both postmeal ghrelin and hunger, and tested whether these links differed for people with a higher versus lower body mass index (BMI; kg/m(2)). During this double-blind randomized crossover study, women (N=42) ate a high saturated fat meal at the beginning of one full-day visit and a high oleic sunflower oil meal at the beginning of the other. Loneliness was assessed once with a commonly used loneliness questionnaire. Ghrelin was sampled before the meal and postmeal at 2 and 7h. Self-reported hunger was measured before the meal, immediately postmeal, and then 2, 4, and 7h later. Lonelier women had larger postprandial ghrelin and hunger increases compared with less lonely women, but only among participants with a lower BMI. Loneliness and postprandial ghrelin and hunger were unrelated among participants with a higher BMI. These effects were consistent across both meals. These data suggest that ghrelin, an important appetite-regulation hormone, and hunger may link loneliness to weight gain and its corresponding negative health effects among non-obese people.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.