ArticleDevelopment (Cambridge, England)2015
teashirt is required for head-versus-tail regeneration polarity in planarians.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration.PLoS genetics · 2025Article
- Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.Heliyon · 2025Review
- Article
- Genome-wide transcriptome analysis ofFrontiers in cellular and infection microbiology · 2024Article
- Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.Nature communications · 2023Article
- An insight into planarian regeneration.Cell proliferation · 2022Review
- Src acts with WNT/FGFRL signaling to pattern the planarian anteroposterior axis.Development (Cambridge, England) · 2022Article
- Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals.Nature communications · 2021Article
- Article
- Panarthropod tiptop/teashirt and spalt orthologs and their potential role as "trunk"-selector genes.EvoDevo · 2021Article
- activin-2 is required for regeneration of polarity on the planarian anterior-posterior axis.PLoS genetics · 2021Article
- STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling.Current biology : CB · 2020Article
- A small set of conserved genes, including sp5 and Hox, are activated by Wnt signaling in the posterior of planarians and acoels.PLoS genetics · 2019Article
- Review
- Positional information specifies the site of organ regeneration and not tissue maintenance in planarians.eLife · 2018Article
- A C-terminally truncated form of β-catenin acts as a novel regulator of Wnt/β-catenin signaling in planarians.PLoS genetics · 2017Article
- Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians.Development (Cambridge, England) · 2017Article
- Go ahead, grow a head! A planarian's guide to anterior regeneration.Regeneration (Oxford, England) · 2016Review
- Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration.eLife · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Regeneration requires that the identities of new cells are properly specified to replace missing tissues. The Wnt signaling pathway serves a central role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc-finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals and at posterior-facing wounds. Inhibition of Smed-teashirt (teashirt) by RNA interference (RNAi) resulted in the regeneration of heads in place of tails, a phenotype previously observed with RNAi of the Wnt pathway genes β-catenin-1, wnt1, Dvl-1/2 or wntless. teashirt was required for β-catenin-1-dependent activation of posterior genes during regeneration. These findings identify teashirt as a transcriptional target of Wnt signaling required for Wnt-mediated specification of posterior blastemas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.