ArticleCerebral cortex (New York, N.Y. : 1991)2016
Short-Term Memory Depends on Dissociable Medial Temporal Lobe Regions in Amnestic Mild Cognitive Impairment.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Medial temporal lobe atrophy in Down syndrome along the Alzheimer's disease continuum.Brain : a journal of neurology · 2025Article
- Postmortem imaging reveals patterns of medial temporal lobe vulnerability to tau pathology in Alzheimer's disease.Nature communications · 2024Article
- Automated High-Definition MRI Processing Routine Robustly Detects Longitudinal Morphometry Changes in Alzheimer's Disease Patients.Frontiers in aging neuroscience · 2022Article
- Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe.Brain : a journal of neurology · 2021Article
- Investigation of the relationship between visual feature binding in short- and long-term memory in healthy aging.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease.Human brain mapping · 2019Article
- Associative memory for conceptually unitized word pairs in mild cognitive impairment is related to the volume of the perirhinal cortex.Hippocampus · 2019Article
- Longitudinal Mapping of Cortical Thickness Measurements: An Alzheimer's Disease Neuroimaging Initiative-Based Evaluation Study.Journal of Alzheimer's disease : JAD · 2019Article
- Alzheimer's disease patients activate attention networks in a short-term memory task.NeuroImage. Clinical · 2019Article
- Diminution of context association memory structure in subjects with subjective cognitive decline.Human brain mapping · 2018Article
- Episodic Memory and Beyond: The Hippocampus and Neocortex in Transformation.Annual review of psychology · 2016Review
- Suspected non-AD pathology in mild cognitive impairment.Neurobiology of aging · 2015Article
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Authors and funding
5 authors.
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Abstract
Short-term memory (STM) has generally been thought to be independent of the medial temporal lobe (MTL) in contrast to long-term memory (LTM). Prodromal Alzheimer's disease (AD) is a condition in which the MTL is a major early focus of pathology and LTM is thought disproportionately affected relative to STM. However, recent studies have suggested a role for the MTL in STM, particularly hippocampus, when binding of different elements is required. Other work has suggested involvement of extrahippocampal MTL structures, particularly in STM tasks that involve item-level memory. We examined STM for individual objects, locations, and object-location conjunctions in amnestic mild cognitive impairment (MCI), often associated with prodromal AD. Relative to age-matched, cognitively normal controls, MCI patients not only displayed impairment on object-location conjunctions but were similarly impaired for non-bound objects and locations. Moreover, across all participants, these conditions displayed dissociable correlations of cortical thinning along the long axis of the MTL and associated cortical nodes of anterior and posterior MTL networks. These findings support the role of the MTL in visual STM tasks and the division of labor of MTL in support of different types of memory representations, overlapping with findings in LTM.
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