Evidence map›Paper›PMID 25724933›Full record

ArticlePflugers Archiv : European journal of physiology2015

Acute temperature sensitivity in optic nerve axons explained by an electrogenic membrane potential.

Tom A Coates, Oscar Woolnough, Joseph M Masters, Gulsum Asadova, Charmilie Chandrakumar, Mark D Baker

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Diuretic-sensitive electroneutral NaThe Journal of physiology · 2017
    Article
  6. Some do not like it hot.The Journal of physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tom A CoatesNeuroscience and Trauma Centre, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E12AT, UK.
Oscar WoolnoughNeuroscience and Trauma Centre, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E12AT, UK.
Joseph M MastersNeuroscience and Trauma Centre, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E12AT, UK.
Gulsum AsadovaNeuroscience and Trauma Centre, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E12AT, UK.
Charmilie ChandrakumarNeuroscience and Trauma Centre, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E12AT, UK.
Mark D BakerNeuroscience and Trauma Centre, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E12AT, UK. m.d.baker@qmul.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classical work in squid axon reports resting membrane potential is independent of temperature, but our findings suggest that this is not the case for axons in mammalian optic nerve. Refractory period duration changes over 10 times between 37 °C and room temperature, and afterpotential polarity is also acutely temperature sensitive, inconsistent with changes in temperature impacting nerve function only through altered rates of ion channel gating kinetics. Our evidence suggests that the membrane potential is enhanced by warming, an effect reduced by exposure to ouabain. The temperature dependence can be explained if axonal Na(+)/K(+) ATPase continuously expels Na(+) ions that enter axons largely electroneutrally, thereby adding a substantial electrogenic component to the membrane potential. Block of the Na(+) transporter NKCC1 with bumetanide increases refractoriness, like depolarization, indicating that this is a probable route by which Na(+) enters, raising the expectation that the rate of electroneutral Na(+) influx increases with temperature and suggesting a temperature-dependent transmembrane Na(+) cycle that contributes to membrane potential.

Indexed as

AnimalsAxonsBumetanideElectrophysiological PhenomenaEnzyme InhibitorsFemaleMaleMembrane PotentialsMiceMice, Inbred C57BLOptic NerveOuabainPotassium Channel BlockersRatsRats, WistarRefractory Period, ElectrophysiologicalBumetanideEnzyme InhibitorsOuabainPotassium Channel BlockersSlc12a2 protein, ratSodiumSodium-Potassium-Exchanging ATPaseSolute Carrier Family 12, Member 2BumetanideMembrane potentialNa+/K+-ATPaseNKCC1Optic nerveOuabainRecovery cycle

Identifiers

PMID25724933

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.