Evidence map›Paper›PMID 25724921›Full record

ArticleToxicological sciences : an official journal of the Society of Toxicology2015

Pharmacokinetic evaluation of the equivalency of gavage, dietary, and drinking water exposure to manganese in F344 rats.

Melanie L Foster, Thomas B Bartnikas, Laura C Johnson, Carolina Herrera, Michael A Pettiglio, Athena M Keene, Michael D Taylor, David C Dorman

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicological sciences : an official journal of the Society of Toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Scientific opinion on the tolerable upper intake level for manganese.EFSA journal. European Food Safety Authority · 2023
    Article
  2. Article
  3. Article
  4. Toxicity associated with ingestion of a polyacrylic acid hydrogel dog pad.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018
    Article
  5. Article
  6. The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Melanie L Foster*North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Rm. 522, Providence, Rhode Island 02912, USA, Afton Chemical Corporation, 500 Spring Street, Richmond, Virginia 23219, USA and Nickel Producers Environmental Research Association (NiPERA), 2525 Meridian Parkway, Suite 240 Durham, North Carolina 27713, USA.
Thomas B Bartnikas*North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Rm. 522, Providence, Rhode Island 02912, USA, Afton Chemical Corporation, 500 Spring Street, Richmond, Virginia 23219, USA and Nickel Producers Environmental Research Association (NiPERA), 2525 Meridian Parkway, Suite 240 Durham, North Carolina 27713, USA.
Laura C Johnson*North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Rm. 522, Providence, Rhode Island 02912, USA, Afton Chemical Corporation, 500 Spring Street, Richmond, Virginia 23219, USA and Nickel Producers Environmental Research Association (NiPERA), 2525 Meridian Parkway, Suite 240 Durham, North Carolina 27713, USA.
Carolina Herrera*North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Rm. 522, Providence, Rhode Island 02912, USA, Afton Chemical Corporation, 500 Spring Street, Richmond, Virginia 23219, USA and Nickel Producers Environmental Research Association (NiPERA), 2525 Meridian Parkway, Suite 240 Durham, North Carolina 27713, USA.
Michael A Pettiglio*North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Rm. 522, Providence, Rhode Island 02912, USA, Afton Chemical Corporation, 500 Spring Street, Richmond, Virginia 23219, USA and Nickel Producers Environmental Research Association (NiPERA), 2525 Meridian Parkway, Suite 240 Durham, North Carolina 27713, USA.
Athena M Keene*North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Rm. 522, Providence, Rhode Island 02912, USA, Afton Chemical Corporation, 500 Spring Street, Richmond, Virginia 23219, USA and Nickel Producers Environmental Research Association (NiPERA), 2525 Meridian Parkway, Suite 240 Durham, North Carolina 27713, USA.
Michael D Taylor*North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Rm. 522, Providence, Rhode Island 02912, USA, Afton Chemical Corporation, 500 Spring Street, Richmond, Virginia 23219, USA and Nickel Producers Environmental Research Association (NiPERA), 2525 Meridian Parkway, Suite 240 Durham, North Carolina 27713, USA.
David C Dorman*North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA, Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Rm. 522, Providence, Rhode Island 02912, USA, Afton Chemical Corporation, 500 Spring Street, Richmond, Virginia 23219, USA and Nickel Producers Environmental Research Association (NiPERA), 2525 Meridian Parkway, Suite 240 Durham, North Carolina 27713, USA david_dorman@NCSU.edu.
North Carolina State University · US

Funding

Interdisciplinary Biomedical Research Training ProgramT35OD011070 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Ronald Hak Long Li · 2012 to 2026
$1.1M
Regulation of mammalian iron homeostasis by iron and transferrinR00DK084122 · NIDDK · BROWN UNIVERSITY · PI BARTNIKAS, THOMAS BENEDICT · 2013 to 2015
$722k
NIDDK NIH HHS R00 DK084122NIH HHS T35 OD011070
6 · The paper itself

Abstract

Concerns exist as to whether individuals may be at greater risk for neurotoxicity following increased manganese (Mn) oral intake. The goals of this study were to determine the equivalence of 3 methods of oral exposure and the rate (mg Mn/kg/day) of exposure. Adult male rats were allocated to control diet (10 ppm), high manganese diet (200 ppm), manganese-supplemented drinking water, and manganese gavage treatment groups. Animals in the drinking water and gavage groups were given the 10 ppm manganese diet and supplemented with manganese chloride (MnCl(2)) in drinking water or once-daily gavage to provide a daily manganese intake equivalent to that seen in the high-manganese diet group. No statistically significant difference in body weight gain or terminal body weights was seen. Rats were anesthetized following 7 and 61 exposure days, and samples of bile and blood were collected. Rats were then euthanized and striatum, olfactory bulb, frontal cortex, cerebellum, liver, spleen, and femur samples were collected for chemical analysis. Hematocrit was unaffected by manganese exposure. Liver and bile manganese concentrations were elevated in all treatment groups on day 61 (relative to controls). Increased cerebellum manganese concentrations were seen in animals from the high-manganese diet group (day 61, relative to controls). Increased (relative to all treatment groups) femur, striatum, cerebellum, frontal cortex, and olfactory bulb manganese concentrations were also seen following gavage suggesting that dose rate is an important factor in the pharmacokinetics of oral manganese. These data will be used to refine physiologically based pharmacokinetic models, extending their utility for manganese risk assessment by including multiple dietary exposures.

Indexed as

DietFood ContaminationAdministration, OralAnimalsBody BurdenChloridesMaleManganese CompoundsManganese PoisoningRats, Inbred F344Risk AssessmentTissue DistributionWater Pollutants, ChemicalChloridesmanganese chlorideManganese CompoundsWater Pollutants, Chemicaldose ratemanganeseoral exposurepharmacokinetics

Identifiers

PMID25724921
PMCPMC4490190
OpenAlexW2154758118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.