ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2015
Increased Risk of Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients With Active Celiac Disease on Biopsy.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026Review
- Article
- Association of celiac disease with eosinophilic esophagitis: Nationwide register-based cohort study with sibling analyses.The journal of allergy and clinical immunology. Global · 2024Article
- Challenging assumptions about the demographics of eosinophilic gastrointestinal diseases: A systematic review.The journal of allergy and clinical immunology. Global · 2024Article
- Epidemiologic and Clinical Clues to the Etiology of Eosinophilic Esophagitis.Immunology and allergy clinics of North America · 2024Review
- Coeliac disease is a strong risk factor for Gastro-oesophageal reflux disease while a gluten free diet is protective: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Prevalence of Esophageal Eosinophilia, Eosinophilic Esophagitis, and Lymphocytic Gastritis in Children with Celiac Disease: A Saudi Tertiary Center Experience.Canadian journal of gastroenterology & hepatology · 2024Article
- Otorhinolaryngological Manifestations and Esophageal Disorders in Celiac Disease: A Narrative Review.Journal of clinical medicine · 2023Review
- Food Allergy Characteristics Associated With Coexisting Eosinophilic Esophagitis in FARE Registry Participants.The journal of allergy and clinical immunology. In practice · 2023Article
- Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2022Article
- Upper gastrointestinal endoscopic findings in celiac disease at diagnosis: A multicenter international retrospective study.World journal of gastroenterology · 2022Observational
- Eosinophilic esophagitis-established facts and new horizons.Seminars in immunopathology · 2021Review
- A Comprehensive Review of Celiac Disease/Gluten-Sensitive Enteropathies.Clinical reviews in allergy & immunology · 2019Review
- Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.Genes and immunity · 2019Article
- Pathophysiology of Eosinophilic Esophagitis.Clinical reviews in allergy & immunology · 2018Review
- Environmental factors and eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2018Review
- Epidemiology and Natural History of Eosinophilic Esophagitis.Gastroenterology · 2018Review
- Coeliac disease: to biopsy or not?Nature reviews. Gastroenterology & hepatology · 2018Review
- Low yield for non-targeted biopsies of the stomach and esophagus during elective esophagogastroduodenoscopy.Endoscopy international open · 2017Article
- Eosinophilic oesophagitis and coeliac disease: is there an association?BMJ case reports · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsThe possible association between eosinophilic esophagitis (EoE) and celiac disease is controversial because prior results have been contradictory. We aimed to determine the relationship between EoE and celiac disease among patients with concomitant esophageal and duodenal biopsies.
methodsWe conducted a cross-sectional study in a U.S. national pathology database by using data from January 2009 through June 2012. Our primary case definition was defined by the presence of esophageal eosinophilia with ≥15 eosinophils per high-power field. The crude and adjusted (for age and sex) odds of esophageal eosinophilia for patients with active celiac disease were compared with those without celiac disease. Sensitivity analyses were performed by using more stringent case definitions and by estimating the associations between celiac disease and reflux esophagitis and celiac disease and Barrett's esophagus.
resultsOf 292,621 patients in the source population, 88,517 with both esophageal and duodenal biopsies were studied. Four thousand one hundred one (4.6%) met criteria for EoE, and 1203 (1.4%) met criteria for celiac disease. Odds of EoE were 26% higher in patients with celiac disease than in patients without celiac disease (adjusted odds ratio [aOR], 1.26; 95% confidence interval [CI], 0.98-1.60). The magnitude of association varied according to EoE case definition, but all definitions showed a weak positive association between the 2 conditions. There was no association between celiac disease and reflux esophagitis (aOR, 0.95; 95% CI, 0.85-1.07) or Barrett's esophagus (aOR, 0.89; 95% CI, 0.69-1.14) and celiac disease.
conclusionsThere is a weak increase in EoE in patients with celiac disease. This association strengthened with increasingly stringent definitions of EoE and was not observed for other esophageal conditions. In patients with celiac disease, concomitant EoE should be considered in the correct clinical setting.
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