ArticleMolecular and cellular biochemistry2015
Tocopherol isoforms (α-, γ-, and δ-) show distinct capacities to control Nrf-2 and NfκB signaling pathways that modulate inflammatory response in Caco-2 intestinal cells.
Article in Molecular and cellular biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
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- Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.Molecules (Basel, Switzerland) · 2025Review
- Butyrate and tributyrin reduce LPS-induced inflammatory cytokine production from human visceral fat.International journal of obesity (2005) · 2024Article
- The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2-A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients.Antioxidants (Basel, Switzerland) · 2022Review
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- Enjoy Carefully: The Multifaceted Role of Vitamin E in Neuro-Nutrition.International journal of molecular sciences · 2021Review
- Vitamin E beyond Its Antioxidant Label.Antioxidants (Basel, Switzerland) · 2021Review
- Protective Role of Natural and Semi-Synthetic Tocopherols on TNFα-Induced ROS Production and ICAM-1 and Cl-2 Expression in HT29 Intestinal Epithelial Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Potential Protective Effect of Dietary Intake of Non-Oxidative medicine and cellular longevity · 2020Article
- Chlorogenic acid isomers directly interact with Keap 1-Nrf2 signaling in Caco-2 cells.Molecular and cellular biochemistry · 2019Article
- Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity.International journal of molecular sciences · 2018Article
- The Role of Vitamin E in Preventing and Treating Osteoarthritis - A Review of the Current Evidence.Frontiers in pharmacology · 2018Review
- Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.Scientific reports · 2017Article
- Mediterranean diet and inflammaging within the hormesis paradigm.Nutrition reviews · 2017Review
- A blinded, placebo-controlled study on the clinical effects of vitamin E supplementation in dogs with osteoarthritis.Journal of veterinary internal medicineArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently showed that α-, γ-, and δ-tocopherols (Toc) were isoform dependent in modulating an inflammatory response in differentiated human Caco-2 intestinal cells. Here, we aim to investigate the relative capacity of Toc isoforms to modify the stress-activated NfκB and Nrf-2 signaling pathways that regulate the expression of pro-inflammatory cytokines and antioxidant enzymes, respectively, in this well-established in vitro model of the small intestine The modulation of IFNγ/phorbol myristate acetate (PMA)-induced inflammatory responses, determined by the expression of IL8 mRNA and protein, corresponded to the extent by which different Toc isoforms altered intracellular oxidative status in Caco-2 cells. α Toc was more effective at suppressing IFNγ/PMA-induced NfκB activation than γ-Toc, while δ-Toc was ineffective. On the other hand, only δ-Toc and to a lesser extent γ-Toc promoted IFNγ/PMA-induced Nrf-2 activation. Up-regulation of Nrf-2 by δ-Toc coincided with a decrease in GSH/GSSG ratio, thus pointing to pro-oxidant activity of δ-Toc isoform in IFNγ/PMA-stimulated Caco-2 cells. The induction of oxidative stress in IFNγ/PMA-treated cells by δ-Toc was lowered (P < 0.05) in the presence of ascorbic acid. Ascorbic acid also enabled a greater suppression of IL8 secretion than when cells were treated with δ-Toc isoform alone. Our findings show that δ-Toc uniquely promoted oxidative stress which translated to Toc isoform-specific modulation of the stress-activated Nrf-2 and NfκB signaling pathway and an influence on IL8 expression.
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