ArticleThe Journal of biological chemistry2015
δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- δ-catenin controls layer-specific transcriptional maturation of astrocytes via Zbtb20.bioRxiv : the preprint server for biology · 2026Article
- δ-catenin haploinsufficiency is sufficient to alter behaviors and glutamatergic synapses in mice.Neuroscience · 2026Article
- CellScope: high-performance cell atlas workflow with tree-structured representation.Nature communications · 2025Article
- Comparative Single-Cell Transcriptome Analysis of c-Met Receptor Expressing and Non-Expressing Projection Neurons in the Developing Frontal and Visual Cortices.Developmental neuroscience · 2025Article
- Establishment and characterization of Cri Du Chat neuronal stem cells: a novel promising resource to study the syndrome.Human cell · 2025Article
- Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Roles and regulation of δ-catenin in tumorigenesis and neuronal diseases.Frontiers in cell and developmental biology · 2025Review
- Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates.Neuropharmacology · 2024Article
- δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.The Journal of cell biology · 2023Article
- Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.Brain and behavior · 2023Article
- The autism-associated loss of δ-catenin functions disrupts social behavior.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Loss ofFrontiers in neuroscience · 2023Article
- Editorial: Rho family GTPases and their effectors in neuronal survival and neurodegeneration.Frontiers in cellular neuroscience · 2023Article
- p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron developmentFrontiers in cellular neuroscience · 2023Article
- Delta-Catenin as a Modulator of Rho GTPases in Neurons.Frontiers in cellular neuroscience · 2022Review
- Roles of palmitoylation in structural long-term synaptic plasticity.Molecular brain · 2021Review
- Novel phospho-switch function of delta-catenin in dendrite development.The Journal of cell biology · 2020Article
- Disruption ofHGG advances · 2020Article
- δ-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor.The Journal of biological chemistry · 2020Article
- Spatial organization of palmitoyl acyl transferases governs substrate localization and function.Molecular membrane biology · 2019Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ability of neurons to maintain spine architecture and modulate it in response to synaptic activity is a crucial component of the cellular machinery that underlies information storage in pyramidal neurons of the hippocampus. Here we show a critical role for δ-catenin, a component of the cadherin-catenin cell adhesion complex, in regulating spine head width and length in pyramidal neurons of the hippocampus. The loss of Ctnnd2, the gene encoding δ-catenin, has been associated with the intellectual disability observed in the cri du chat syndrome, suggesting that the functional roles of δ-catenin are vital for neuronal integrity and higher order functions. We demonstrate that loss of δ-catenin in a mouse model or knockdown of δ-catenin in pyramidal neurons compromises spine head width and length, without altering spine dynamics. This is accompanied by a reduction in the levels of synaptic N-cadherin. The ability of δ-catenin to modulate spine architecture is critically dependent on its ability to interact with cadherin and PDZ domain-containing proteins. We propose that loss of δ-catenin during development perturbs synaptic architecture leading to developmental aberrations in neural circuit formation that contribute to the learning disabilities in a mouse model and humans with cri du chat syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.