Evidence map›Paper›PMID 25724554›Full record

ArticleSleep & breathing = Schlaf & Atmung2015

Chronic intermittent hypoxia leads to insulin resistance and impaired glucose tolerance through dysregulation of adipokines in non-obese rats.

Cuiping Fu, Liyan Jiang, Fen Zhu, Zilong Liu, Wenjing Li, Hong Jiang, Hongying Ye, Clete A Kushida, Shanqun Li

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Review
  3. Sulfonylurea Use in Patients with Type 2 Diabetes and COPD: A Nationwide Population-Based Cohort Study.International journal of environmental research and public health · 2022
    Article
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  5. Article
  6. Article
  7. Observational
  8. Review
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  10. Article
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  12. Article
  13. Review
  14. Article
  15. [One-hour post-load plasma glucose: a better indicator of glucose metabolism for obstructive sleep apnea?]Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017
    Article
  16. Chronic intermittent hypoxia decreases pulmonary clearance ofAmerican journal of translational research · 2017
    Article
  17. Early improvement in obstructive sleep apnea and increase in orexin levels after bariatric surgery in adolescents and young adults.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017
    Observational
  18. Article
  19. Sleep Apnea in Type 2 Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Cuiping FuDepartment of Respiratory Medicine, Clinical Center for Sleep Breathing Disorder and Snoring, Zhongshan Hospital, Fudan University, Shanghai, China.
Liyan JiangDepartment of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China. jiang_liyan@126.com.
Fen ZhuDepartment of Respiratory Medicine, Clinical Center for Sleep Breathing Disorder and Snoring, Zhongshan Hospital, Fudan University, Shanghai, China.
Zilong LiuDepartment of Respiratory Medicine, Clinical Center for Sleep Breathing Disorder and Snoring, Zhongshan Hospital, Fudan University, Shanghai, China.
Wenjing LiDepartment of Respiratory Medicine, Clinical Center for Sleep Breathing Disorder and Snoring, Zhongshan Hospital, Fudan University, Shanghai, China.
Hong JiangDepartment of Respiratory Medicine, Clinical Center for Sleep Breathing Disorder and Snoring, Zhongshan Hospital, Fudan University, Shanghai, China.
Hongying YeDivision of Endocrinology, Hua Shan Hospital, Fudan University, Shanghai, China. dryehongying@hotmail.com.
Clete A KushidaStanford University Sleep Clinic and Center for Human Sleep Research, Redwood City, CA, USA. clete@stanford.edu.
Shanqun LiDepartment of Respiratory Medicine, Clinical Center for Sleep Breathing Disorder and Snoring, Zhongshan Hospital, Fudan University, Shanghai, China. lsq18616880856@163.com.
Fudan University · CNZhongshan Hospital · CNShanghai Chest Hospital · CNStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe aim of this study was to determine whether chronic intermittent hypoxia (CIH) could affect the secretion of adipokines, such as resistin, leptin, and adiponectin, in non-obese rats and to investigate the potential mechanisms.

methodsAn established rodent model of CIH was utilized, in which rats were exposed to varying oxygen levels (7-21 %) respectively over a period of 5 weeks. The area under the curve (AUCG) and the insulin resistance index (homeostasis model of assessment for insulin resistance index, HOMA-IR) were calculated. The levels of several secretory factors in the blood were measured by enzyme-linked immunosorbent assay (ELISA). The mRNA levels and protein expression in adipose tissues was measured by reverse transcription-polymerase chain reaction (RT-PCR).

resultsGlucose tolerance and the levels of adiponectin in non-obese rats were decreased in the CIH group both in the serum and adipose tissue compared with the controls, while the insulin resistance index and the levels of resistin and leptin were increased. Moreover, the expressions of hypoxia inducible factor-1α and lactate dehydrogenase A were significantly higher in chronic intermittent hypoxia rats than in control rats, suggesting the presence of adipose tissue hypoxia.

conclusionsThese results show that CIH leads to insulin resistance (IR) and impaired glucose tolerance (IGT) in a non-obese rodent model of obstructive sleep apnea-hypopnea syndrome, and these effects may be due to the dysregulation of adiponectin, resistin, and leptin.

Indexed as

AdipokinesAdipose TissueAnimalsBlood GlucoseChronic DiseaseDisease Models, AnimalEnzyme-Linked Immunosorbent AssayHypoxiaInsulinInsulin ResistanceMaleRatsReference ValuesAdipokinesBlood GlucoseInsulinAdipokineChronic intermittent hypoxiaImpaired glucose toleranceInsulin resistanceSleep apnea

Identifiers

PMID25724554
OpenAlexW2022264206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.