Evidence map›Paper›PMID 25724418›Full record

ReviewVirology2015

Reaching the melting point: Degradative enzymes and protease inhibitors involved in baculovirus infection and dissemination.

Egide Ishimwe, Jeffrey J Hodgson, Rollie J Clem, A Lorena Passarelli

Open access · greenAbstract readReview
In one paragraph

Review in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The toxins of vertically transmittedFrontiers in microbiology · 2023
    Article
  6. TheViruses · 2022
    Article
  7. Recombinant Protein Production and Purification of Insoluble Proteins.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Egide IshimweDivision of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS 66506-4901, United States.
Jeffrey J HodgsonDivision of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS 66506-4901, United States.
Rollie J ClemDivision of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS 66506-4901, United States. Electronic address: rclem@ksu.edu.
A Lorena PassarelliDivision of Biology, Kansas State University, 116 Ackert Hall, Manhattan, KS 66506-4901, United States. Electronic address: lpassar@ksu.edu.
Kansas State University · US

Funding

Arbovirus midgut escape mechanismsR01AI091972 · NIAID · KANSAS STATE UNIVERSITY · PI FRANZ, ALEXANDER W E, PASSARELLI, A. LORENA · 2012 to 2015
$2.6M
NIAID NIH HHS R01 AI091972NIAID NIH HHS R01AI091972
6 · The paper itself

Abstract

Baculovirus infection of a host insect involves several steps, beginning with initiation of virus infection in the midgut, followed by dissemination of infection from the midgut to other tissues in the insect, and finally culminating in "melting" or liquefaction of the host, which allows for horizontal spread of infection to other insects. While all of the viral gene products are involved in ultimately reaching this dramatic infection endpoint, this review focuses on two particular types of baculovirus-encoded proteins: degradative enzymes and protease inhibitors. Neither of these types of proteins is commonly found in other virus families, but they both play important roles in baculovirus infection. The types of degradative enzymes and protease inhibitors encoded by baculoviruses are discussed, as are the roles of these proteins in the infection process.

Indexed as

AnimalsBaculoviridaeChitinasesInsectaPeptide HydrolasesProtease InhibitorsChitinasesPeptide HydrolasesProtease InhibitorsBaculovirusCathepsinChitinaseMatrix metalloproteaseODV-E66P35P49Serpin

Identifiers

PMID25724418
PMCPMC4424183
OpenAlexW1970817461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.