Evidence map›Paper›PMID 25724416›Full record

ReviewVirology2015

Beta genus papillomaviruses and skin cancer.

Peter M Howley, Herbert J Pfister

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 192 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. A splice donor inJournal of virology · 2025
    Article
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  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Peter M HowleyDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: peter_howley@hms.harvard.edu.
Herbert J PfisterInstitute of Virology, University of Cologne, Fürst-Pückler-Str. 56, 50935 Cologne, Germany.
Harvard University · USUniversity of Cologne · DE

Funding

VIRAL ONCOPROTEIN PERTURBATION OF RB/E2F PATHWAYP01CA050661 · NCI · DANA-FARBER CANCER INSTITUTE · PI HOWLEY, PETER M · 1989 to 2013
$35.8M
Papillomavirus E2 Functions: Cellular Regulation and EffectorsR01CA116720 · NCI · HARVARD MEDICAL SCHOOL · PI HOWLEY, PETER M · 2006 to 2015
$2.8M
NCI NIH HHS P01 CA050661NCI NIH HHS R01 CA116720
6 · The paper itself

Abstract

A role for the beta genus HPVs in keratinocyte carcinoma (KC) remains to be established. In this article we examine the potential role of the beta HPVs in cancer revealed by the epidemiology associating these viruses with KC and supported by oncogenic properties of the beta HPV proteins. Unlike the cancer associated alpha genus HPVs, in which transcriptionally active viral genomes are invariably found associated with the cancers, that is not the case for the beta genus HPVs and keratinocyte carcinomas. Thus a role for the beta HPVs in KC would necessarily be in the carcinogenesis initiation and not in the maintenance of the tumor.

Indexed as

BetapapillomavirusCarcinogenesisHumansKeratinocytesPapillomavirus InfectionsSkin NeoplasmsCancerEpidemiologyKeratinocyteMAML1NotchPapillomavirus

Identifiers

PMID25724416
PMCPMC4424140
OpenAlexW2034817571

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.