ArticleNature communications2015
AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis root tip.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 1 synthesis or guideline pooled it, 292 citations in OpenAlex.
- A systematic review to identify target genes that modulate root system architecture in response to abiotic stress.Scientific reports · 2025Pooled it
- The primary nitrate response TGA1 and TGA4 transcription factors are negative regulators of sulfate uptake and metabolism.Plant physiology · 2026Article
- Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual-Purpose Defense Metabolite inPlant direct · 2026Article
- TaPHL7 Transcription Factor Regulates Utilisation of Nitrogen and Phosphorus in Wheat.Plant biotechnology journal · 2026Article
- Nitrogen Management in Crop-Soil-Environment Systems: Pathways Toward Sustainable and Climate-Resilient Agriculture.International journal of molecular sciences · 2026Review
- Integrated Gene Regulatory Network Analysis Reveals Coordinated Transcriptional Reprogramming in thePlants (Basel, Switzerland) · 2026Article
- Nitrogen starvation induces arbuscular mycorrhizal fungi to optimize resource allocation in sugarcane roots via suppression of basal metabolism.NPJ biofilms and microbiomes · 2026Article
- Iron deficiency changes regulatory mechanisms governing sieve element cell differentiation.Nature communications · 2025Article
- Genome-wide identification and expression analysis of the GARP superfamily in response to abiotic stresses in alfalfa (Medicago sativa L.).BMC plant biology · 2025Article
- Evolutionary trajectory of the NPF6.3(NRT1.1/CHL1)-centered nitrate signaling regulatory network in plant roots.BMC plant biology · 2025Article
- Characterization of transcriptional and metabolic responses to a complex plant growth-promoting soil inoculum.Plant biology (Stuttgart, Germany) · 2025Article
- Physiological and transcriptomic analysis reveal the response mechanisms to nutrient deficiencies in aquatic plant Spirodela polyrhiza.Plant molecular biology · 2025Article
- Designing a nitrogen-efficient cold-tolerant maize for modern agricultural systems.The Plant cell · 2025Review
- Conservation and divergence of regulatory architecture in nitrate-responsive plant gene circuits.The Plant cell · 2025Article
- Harnessing the Potential of CRISPR/Cas in Targeted Alfalfa Improvement for Stress Resilience.International journal of molecular sciences · 2025Review
- Genome-Wide Identification and Comprehensive Analysis of the GARP Transcription Factor Superfamily inGenes · 2025Article
- TaTCP6 is required for efficient and balanced utilization of nitrate and phosphorus in wheat.Nature communications · 2025Article
- Down-regulation of the rice HRS1 HOMOLOG3 transcriptional repressor gene due to N deficiency directly co-activates ammonium and phosphate transporter genes.Journal of experimental botany · 2025Article
- Rice transcription factorsFrontiers in plant science · 2025Article
- Crossed wires: diatom phosphate sensing mechanisms coordinate nitrogen metabolism.Plant signaling & behavior · 2024Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Nitrogen and phosphorus are among the most widely used fertilizers worldwide. Nitrate (NO3(-)) and phosphate (PO4(3-)) are also signalling molecules whose respective transduction pathways are being intensively studied. However, plants are continuously challenged with combined nutritional deficiencies, yet very little is known about how these signalling pathways are integrated. Here we report the identification of a highly NO3(-)-inducible NRT1.1-controlled GARP transcription factor, HRS1, document its genome-wide transcriptional targets, and validate its cis-regulatory elements. We demonstrate that this transcription factor and a close homologue repress the primary root growth in response to P deficiency conditions, but only when NO3(-) is present. This system defines a molecular logic gate integrating P and N signals. We propose that NO3(-) and P signalling converge via double transcriptional and post-transcriptional control of the same protein, HRS1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.