ArticleAnnals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft2015
Sex-differences of the healthy infra-patellar (Hoffa) fat pad in relation to intermuscular and subcutaneous fat content--data from the Osteoarthritis Initiative.
Article in Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Impact of Diet and/or Exercise Intervention on Infrapatellar Fat Pad Morphology: Secondary Analysis from the Intensive Diet and Exercise for Arthritis (IDEA) Trial.Cells, tissues, organs · 2017Trial
- The association between infrapatellar fat pad volume and knee pain in non-obese postmenopausal women.Osteoarthritis imaging · 2026Article
- Infrapatellar Fat Pad in Knee Osteoarthritis: A Comprehensive Review of Pathophysiology and Targeted Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Infrapatellar fat pad stiffness is associated with knee symptoms in patients with knee osteoarthritis.Clinical rheumatology · 2025Article
- Measurement of periarticular subcutaneous fat on CT images and adverse outcomes following total knee arthroplasty.Journal of orthopaedics · 2025Article
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- Dynamic Changes in Muscle Thickness and Infrapatellar Fat Pad During Quadriceps Setting: An Ultrasound Echo Analysis.Cureus · 2024Article
- Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?Osteoarthritis and cartilage open · 2024Review
- Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis.Osteoarthritis and cartilage · 2024Article
- Association between infrapatellar fat pad ultrasound elasticity and anterior knee pain in patients with knee osteoarthritis.Scientific reports · 2023Article
- Exploring Anatomo-Morphometric Characteristics of Infrapatellar, Suprapatellar Fat Pad, and Knee Ligaments in Osteoarthritis Compared to Post-Traumatic Lesions.Biomedicines · 2022Article
- Morphological characteristics of the infrapatellar fat pad.Scientific reports · 2022Article
- The Corpus Adiposum Infrapatellare (Hoffa's Fat Pad)-The Role of the Infrapatellar Fat Pad in Osteoarthritis Pathogenesis.Biomedicines · 2022Review
- Serum adipokines/related inflammatory factors and ratios as predictors of infrapatellar fat pad volume in osteoarthritis: Applying comprehensive machine learning approaches.Scientific reports · 2020Article
- Calorie restriction with regular chow, but not a high-fat diet, delays onset of spontaneous osteoarthritis in the Hartley guinea pig model.Arthritis research & therapy · 2019Article
- Correlation between subcutaneous fat measurements in knee MRI and BMI: relationship to obesity and related co-morbidities.Acta radiologica open · 2019Article
- Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP).Arthritis research & therapy · 2017Article
- Between-group differences in infra-patellar fat pad size and signal in symptomatic and radiographic progression of knee osteoarthritis vs non-progressive controls and healthy knees - data from the FNIH Biomarkers Consortium Study and the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2017Article
- Sonographic characterization of Hoffa's fat pad. A pilot study.Rheumatology international · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The infra-patellar fat pad (IPFP) is composed of intra-articular adipose tissue; it represents a potential source of pro-inflammatory cytokines and has been associated with osteoarthritis of the knee. Yet, to what extent the size of the IPFP differs between healthy men and women, and how sex differences compare to those in inter-muscular and subcutaneous fat tissue content is unknown. We studied healthy reference subjects from the Osteoarthritis Initiative, without knee pain, without radiographic signs or without risk factors of femorotibial osteoarthritis. Sagittal magnetic resonance images (MRIs) of 99 right knees were used to segment the IPFP; in a subset, axial images of the thigh were available to segment inter-muscular and subcutaneous fat. Healthy men (n=40) displayed a 41% greater (p<0.001) IPFP volume and a 9% greater (p<0.01) ratio of IPFP volume/body weight than women (n=59). Men (n=13) displayed 15% greater intermuscular fat content (not significant), and a 50% lesser (p<0.01) subcutaneous fat content than women (n=12); when related to total thigh cross-sectional areas, these sex differences were +2% (not significant) and -53% (p<0.001). This is the first study to explore quantitative measures of the IPFP in healthy men and women, and to relate these to sex differences of inter-muscular and subcutaneous fat tissue content. Men displayed a significantly greater ratio of IPFP volume/body weight than women, similar amounts of inter-muscular fat, and strikingly less subcutaneous fat. These data provide a basis for further systematic studies of the variability of the IPFP with the body mass index and its role in knee osteoarthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.