ArticleOptics letters2015
Cherenkov-excited luminescence scanned imaging.
Article in Optics letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Oxygels: Tunable Phosphorescent Hydrogels for Cherenkov-Excited Luminescence Imaging (CELI) of Oxygen.Advanced healthcare materials · 2026Article
- Radiotherapy beam tracking by dual-modality injectable fiducial marker for X-ray CT and Cherenkov luminescence imaging.Biomedical optics express · 2026Article
- Multiscale local sparsity and prior learning algorithm for Cherenkov-excited luminescence scanned tomography reconstruction.Applied optics · 2025Article
- Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy.Frontiers in medicine · 2025Review
- Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.Chemical reviews · 2024Review
- Selfrec-Net: self-supervised deep learning approach for the reconstruction of Cherenkov-excited luminescence scanned tomography.Biomedical optics express · 2023Article
- X-ray Cherenkov-luminescence tomography reconstruction with a three-component deep learning algorithm: Swin transformer, convolutional neural network, and locality module.Journal of biomedical optics · 2023Article
- High-Resolution pOInternational journal of radiation oncology, biology, physics · 2021Article
- Review of in vivo optical molecular imaging and sensing from x-ray excitation.Journal of biomedical optics · 2021Review
- Single pixel hyperspectral Cherenkov-excited fluorescence imaging with LINAC X-ray sheet scanning and spectral unmixing.Optics letters · 2020Article
- Theoretical lateral and axial sensitivity limits and choices of molecular reporters for Cherenkov-excited luminescence in tissue during x-ray beam scanning.Journal of biomedical optics · 2020Article
- Tracking tumor radiotherapy response in vivo with Cherenkov-excited luminescence ink imaging.Physics in medicine and biology · 2020Article
- Tissue pONature communications · 2020Article
- Radioluminescence in biomedicine: physics, applications, and models.Physics in medicine and biology · 2019Review
- Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine.Journal of biomedical optics · 2018Review
- Multi-beam scan analysis with a clinical LINAC for high resolution Cherenkov-excited molecular luminescence imaging in tissue.Biomedical optics express · 2018Article
- Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging.Seminars in nuclear medicine · 2018Review
- Signal intensity analysis and optimization for in vivo imaging of Cherenkov and excited luminescence.Physics in medicine and biology · 2018Article
- Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging.Nature biomedical engineering · 2018Article
- Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom.Journal of biomedical optics · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Ionizing radiation is commonly delivered by medical linear accelerators (LINAC) in the form of shaped beams, and it is able to induce Cherenkov emission in tissue. In fluorescence-based microscopy excitation from scanned spots, lines, or sheets can be used for fast high-resolution imaging. Here we introduce Cherenkov-excited luminescence scanned imaging (CELSI) as a new imaging methodology utilizing 2-dimensional (∼5-mm-thick) sheets of LINAC radiation to produce Cherenkov photons, which in turn excite luminescence of probes distributed in biological tissues. Imaging experiments were performed by scanning these excitation sheets in three orthogonal directions while recording Cherenkov-excited luminescence. Tissue phantom studies have shown that single luminescent inclusions ∼1 mm in diameter can be imaged within 20-mm-thick tissue-like media with minimal loss of spatial resolution. Using a phosphorescent probe for oxygen, PtG4 with the CELSI methodology, an image of partial pressure of oxygen (pO₂) was imaged in a rat lymph node, quantitatively restoring pO₂ values in differently oxygenated tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.