ReviewCurrent opinion in chemical biology2015
Novel selection methods for DNA-encoded chemical libraries.
Review in Current opinion in chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Allosteric regulation and inhibition of protein kinases.Biochemical Society transactions · 2023Review
- Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization.Chemical reviews · 2022Review
- Learning the structure-activity relationship (SAR) of the Wittig reaction from genetically-encoded substrates.Chemical science · 2021Article
- DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges.ACS pharmacology & translational science · 2021Review
- Selective Modulation of Dynamic Protein Complexes.Cell chemical biology · 2020Review
- Mechanisms of Action for Small Molecules Revealed by Structural Biology in Drug Discovery.International journal of molecular sciences · 2020Review
- Selection of Small Molecules that Bind to and Activate the Insulin Receptor from a DNA-Encoded Library of Natural Products.iScience · 2020Article
- DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials.Topics in current chemistry (Cham) · 2020Review
- Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis.Bioconjugate chemistry · 2019Article
- Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery.Molecules (Basel, Switzerland) · 2019Review
- A Mild, DNA-Compatible Nitro Reduction Using BOrganic letters · 2019Article
- Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets.Molecules and cells · 2018Review
- Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.Nature chemistry · 2018Article
- DNA-encoded chemical libraries - achievements and remaining challenges.FEBS letters · 2018Review
- Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8.SLAS discovery : advancing life sciences R & D · 2018Article
- The In Situ Enzymatic Screening (ISES) Approach to Reaction Discovery and Catalyst Identification.Current protocols in chemical biology · 2017Article
- Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries.Chembiochem : a European journal of chemical biology · 2017Article
- Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity.Angewandte Chemie (International ed. in English) · 2017Article
- Automated screening for small organic ligands using DNA-encoded chemical libraries.Nature protocols · 2016Article
- Design, preparation, and selection of DNA-encoded dynamic libraries.Chemical science · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Driven by the need for new compounds to serve as biological probes and leads for therapeutic development and the growing accessibility of DNA technologies including high-throughput sequencing, many academic and industrial groups have begun to use DNA-encoded chemical libraries as a source of bioactive small molecules. In this review, we describe the technologies that have enabled the selection of compounds with desired activities from these libraries. These methods exploit the sensitivity of in vitro selection coupled with DNA amplification to overcome some of the limitations and costs associated with conventional screening methods. In addition, we highlight newer techniques with the potential to be applied to the high-throughput evaluation of DNA-encoded chemical libraries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.