ArticleBioMed research international2015
The influence of tea tree oil (Melaleuca alternifolia) on fluconazole activity against fluconazole-resistant Candida albicans strains.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Meta-analysis of the antifungal activities of three essential oils as alternative therapies in dermatophytosis infections.Journal of applied microbiology · 2022Pooled it
- Nano-Enabled Advances in Tea Tree Essential Oil (Materials (Basel, Switzerland) · 2026Review
- Article
- Antimicrobial activity of tea tree and lavender essential oils and their effects on hatching performance and eggshell bacterial count of Japanese quail eggs.BMC veterinary research · 2025Article
- Antifungal Activity of Tea Tree (Journal of fungi (Basel, Switzerland) · 2024Article
- The antimicrobial activity of tea tree oil (PeerJ · 2024Article
- Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine.Antibiotics (Basel, Switzerland) · 2022Review
- Antifungal Activity ofMolecules (Basel, Switzerland) · 2022Article
- Potential Use of Tea Tree Oil as a Disinfectant Agent against Coronaviruses: A Combined Experimental and Simulation Study.Molecules (Basel, Switzerland) · 2022Article
- Chemical and Biological Characterization ofPlants (Basel, Switzerland) · 2022Article
- Natural Compounds: A Hopeful Promise as an Antibiofilm Agent AgainstFrontiers in pharmacology · 2022Review
- The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of PluronicInternational journal of molecular sciences · 2021Article
- Essential Oils ofPharmaceutics · 2021Review
- Evaluation of Effectiveness of a Toothpaste Containing Tea Tree Oil and Ethanolic Extract of Propolis on the Improvement of Oral Health in Patients Using Removable Partial Dentures.Molecules (Basel, Switzerland) · 2021Article
- An Overview of the Potential Therapeutic Applications of Essential Oils.Molecules (Basel, Switzerland) · 2021Review
- Bicontinuous microemulsions containing Melaleuca alternifolia essential oil as a therapeutic agent for cutaneous wound healing.Drug delivery and translational research · 2020Article
- Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery.Antibiotics (Basel, Switzerland) · 2020Article
- Essential Oils and Mono/bi/tri-Metallic Nanocomposites as Alternative Sources of Antimicrobial Agents to Combat Multidrug-Resistant Pathogenic Microorganisms: An Overview.Molecules (Basel, Switzerland) · 2020Review
- Enhanced Killing ofMolecules (Basel, Switzerland) · 2019Article
- Essential Oils as Antimicrobial Agents-Myth or Real Alternative?Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the activity of fluconazole against 32 clinical strains of fluconazole-resistant Candida albicans, and C. albicans ATCC 10231 reference strain, after their exposure to sublethal concentrations of tea tree oil (TTO) or its main bioactive component terpinen-4-ol. For all tested fluconazole-resistant C. albicans strains TTO and terpinen-4-ol minimal inhibitory concentrations (MICs) were low, ranging from 0.06% to 0.5%. The 24-hour exposure of fluconazole-resistant C. albicans strains to fluconazole with sublethal dose of TTO enhanced fluconazole activity against these strains. Overall, 62.5% of isolates were classified as susceptible, 25.0% exhibited intermediate susceptibility, and 12.5% were resistant. For all of the tested clinical strains the fluconazole MIC decreased from an average of 244.0 μg/mL to an average of 38.46 μg/mL, and the fluconazole minimal fungicidal concentrations (MFC) decreased from an average of 254.67 μg/mL to an average of 66.62 μg/mL. Terpinen-4-ol was found to be more active than TTO, and strongly enhanced fluconazole activity against fluconazole-resistant C. albicans strains. The results of this study demonstrate that combining natural substances such as TTO and conventional drug such as fluconazole, may help treat difficult yeast infections.
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