ArticleBioMedicine2015
Emerging roles of frailty and inflammaging in risk assessment of age-related chronic diseases in older adults: the intersection between aging biology and personalized medicine.
Article in BioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272737 (Effect of Low Intensity Strength Training Combined With Moderate Blood Flow Restriction on Muscle Vasodilatation and Arterial Stiffness in Elders With Low Gait Velocity.), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Low Intensity Strength Training Combined With Moderate Blood Flow Restriction on Muscle Vasodilatation and Arterial Stiffness in Elders With Low Gait Velocity.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- The Effect of Hyperuricemia on Cognitive Impairment: A Cohort Study and Systematic Review.Nutrients · 2026Pooled it
- Tai chi or health education for older adults with hypertension: effects on mental health and psychological resilience to COVID-19.Aging & mental health · 2023Trial
- Predictors of postoperative complications in elderly patients undergoing pulmonary lobectomy: a retrospective cohort study.Frontiers in medicine · 2026Article
- Effect of body shape index trajectories on kidney disease incidence and subsequent death in individuals with type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Relationship of depression and mortality in community-residing elderly individuals: mediating role of frailty and quality of life.BMC geriatrics · 2025Article
- The mediating role of step counts in the relationship between diverse neighbourhood destinations and older adults' physical function.Scientific reports · 2025Article
- Effect of Resistance Training on Older Adults with Sarcopenic Obesity: A Comprehensive Systematic Review and Meta-Analysis of Blood Biomarkers, Functionality, and Body Composition.Nursing reports (Pavia, Italy) · 2025Review
- Research on Prediction of Multiple Degenerative Diseases and Biomarker Screening Based on DNA Methylation.International journal of molecular sciences · 2025Article
- Park proximity and all-day and time-specific physical activity and sedentary behaviour in older adults.BMC geriatrics · 2024Article
- Inflammatory markers and physical frailty: towards clinical application.Immunity & ageing : I & A · 2024Review
- Early time-restricted feeding improves high-density lipoprotein amount and function in nonhuman primates, without effects on body composition.Obesity (Silver Spring, Md.) · 2023Article
- Prevalence of frailty and pre-frailty and related factors in older adults with cardio-cerebral vascular disease in China: a national cross-sectional study.Frontiers in public health · 2023Article
- Epidemiological status and associated factors of frailty and pre-frailty in older adults with asthma in China: A national cross-sectional study.Frontiers in public health · 2023Article
- Article
- Estrogen rapid effects: a window of opportunity for the aging brain?Neural regeneration research · 2022Review
- Assessing the impact of public transfer payments on the vulnerability of rural households to healthcare poverty in China.BMC health services research · 2022Article
- TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook.Oxidative medicine and cellular longevity · 2022Review
- C-reactive Protein as a Prognostic Marker of 1-Year Mortality after Transcatheter Aortic Valve Implantation in Aortic Stenosis.Arquivos brasileiros de cardiologia · 2021Article
- Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers.International journal of environmental research and public health · 2021Review
- Serum Inflammatory Factors and Oxidative Stress Factors Are Associated With Increased Risk of Frailty and Cognitive Frailty in Patients With Cerebral Small Vessel Disease.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A chronic disease in older adults usually runs a course that is less predictable than in younger individuals. Unexplained variations in disease incidence, prognosis, therapeutic responses, and toxicity are frequently observed among older adults. This heterogeneity poses huge challenges to the current one-size-fits-all health care systems, and calls for more personalized managements of chronic diseases in older adults. Aging is characterized by progressive deterioration of bodily functions with increasing risk of failure over time. The entire process is hierarchically organized, and progresses from intracellular events to changes at systemic and ultimately organism levels at different rates among different individuals. Aging biology exerts great influences on the development and progression of most age-related chronic diseases. Thus, aging biology could contribute to the complexity of illnesses that increase with age, and aging biomarkers possess a great potential to enable personalized health risk assessment and health care. We review evidences supporting the roles of aging biomarkers in risk assessment of prevalent age-related diseases. Frailty phenotype is an objectively measured indicator of advanced-stage aging that is characterized by organism-level dysfunction. In contrast, altered inflammation markers level signifies an earlier stage between cellular abnormalities and systems dysfunction. Results of human observational studies and randomized controlled trials indicate that these measures, albeit simple, greatly facilitate classification of older patients with cancer, chronic kidney disease, cardiovascular diseases and type 2 diabetes mellitus into groups that vary in disease incidence, prognosis and therapeutic response/toxicity. As the detailed mechanisms underlying the complex biologic process of aging are unraveled in the future, a larger array of biomarkers that correlate with biologic aging at different stages will be discovered. Following the translational research framework described in this article, these research efforts would result in innovations in disease prevention and management that address the huge unmet health needs of aging populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.