Evidence map›Paper›PMID 25722915›Full record

ArticleParkinson's disease2015

Effect of exercise on motor and nonmotor symptoms of Parkinson's disease.

Khashayar Dashtipour, Eric Johnson, Camellia Kani, Kayvan Kani, Ehsan Hadi, Mark Ghamsary, Shant Pezeshkian, Jack J Chen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinson's disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06324422 (Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?), which is not on this map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06324422 narecruitingnot on this mapstarted 2024, after this paper: background citation

Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?

TypeinterventionalSponsorUniversity of AarhusRan2024 to 2026Enrolled94ConditionsParkinson's DiseaseArmsAerobic exercise intervention, Resistance exercise intervention
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  5. Interventions for fatigue in Parkinson's disease.The Cochrane database of systematic reviews · 2015
    Pooled it
  6. The effects of dual-task training with different task priorities on physical performance and cognitive status in patients with Parkinson's disease: a single-blind, randomized controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  20. The role of exercise in Parkinson's Disease.Neurosciences (Riyadh, Saudi Arabia) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khashayar DashtipourDepartment of Neurology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Eric JohnsonDepartment of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92354, USA.
Camellia KaniDepartment of Neurology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Kayvan KaniDepartment of Neurology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Ehsan HadiDepartment of Neurology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Mark GhamsaryDepartment of Epidemiology and Biostatistics, School of Public Health, Loma Linda University, Loma Linda, CA 92354, USA.
Shant PezeshkianDepartment of Neurology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Jack J ChenDepartment of Neurology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA ; Department of Pharmacy Practice, College of Pharmacy, Marshal B. Ketchum University, Fullerton, CA 92831, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. Novel rehabilitation strategies have demonstrated potential benefits for motor and non-motor symptoms of Parkinson's disease (PD). Objective. To compare the effects of Lee Silverman Voice Therapy BIG (LSVT BIG therapy) versus a general exercise program (combined treadmill plus seated trunk and limb exercises) on motor and non-motor symptoms of PD. Methods. Eleven patients with early-mid stage PD participated in the prospective, double-blinded, randomized clinical trial. Both groups received 16 one-hour supervised training sessions over 4 weeks. Outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Modified Fatigue Impact Scale (MFIS). Five patients performed general exercise and six patients performed LSVT BIG therapy. Post-intervention evaluations were conducted at weeks 4, 12 and 24. Results. The combined cohort made improvements at all follow-up evaluations with statistical significance for UPDRS total and motor, BDI, and MFIS (P < 0.05). Conclusion. This study demonstrated positive effects of general exercise and LSVT BIG therapy on motor and non-motor symptoms of patients with PD. Our results suggest that general exercise may be as effective as LSVT BIG therapy on symptoms of PD for patients not able to readily access outpatient LSVT BIG therapy.

Identifiers

PMID25722915
PMCPMC4333331

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.