ArticleOxidative medicine and cellular longevity2015
A new approach to oxidative stress and inflammatory signaling during labour in healthy mothers and neonates.
Article in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Oxidative stress biomarkers in fetal growth restriction: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- Omega-3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress.Maternal & child nutrition · 2017Trial
- [The effects of remifentanil used during cesarean section on oxidative stress markers in correlation with maternal hemodynamics and neonatal outcome: a randomized controlled trial].Brazilian journal of anesthesiology (Elsevier)Trial
- Biomarkers of Maternal and Neonatal Oxidative and Nitrosative Stress During Delivery: An Exploratory Pilot Study on Maternal-Neonatal Adaptation to Stress.Journal of clinical medicine · 2026Article
- The Impact of the Delivery Method on Oxidative Stress in Neonates: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Sexual Dimorphism in Cardiometabolic Diseases: From Development to Senescence and Therapeutic Approaches.Cells · 2025Review
- Review
- Effect of mode of delivery on neonatal oxidative stress and dynamic thiol-disulfide homeostasis.The Journal of international medical research · 2023Article
- Comparing maternal and neonatal prooxidant-antioxidant balance during deliveryJournal of the Turkish German Gynecological Association · 2023Article
- A Trace Mineral Injection before Joining and Lambing Increases Marking Percentages and Lamb Weights on Diverse Farms in Victoria, Australia.Animals : an open access journal from MDPI · 2023Article
- Large litter size increases oxidative stress and adversely affects nest-building behavior and litter characteristics in primiparous sows.Frontiers in veterinary science · 2023Article
- Impact of Oxidative Stress on Molecular Mechanisms of Cervical Ripening in Pregnant Women.International journal of molecular sciences · 2022Review
- Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy†.Biology of reproduction · 2021Article
- PROM and Labour Effects on Urinary Metabolome: A Pilot Study.Disease markers · 2018Article
- Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates.Lipids in health and disease · 2017Observational
- Gender specific differences in oxidative stress and inflammatory signaling in healthy term neonates and their mothers.Pediatric research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the current study was to investigate for the first time and simultaneously the oxidative stress and inflammatory signaling induced during the delivery in healthy mothers and their neonates. 56 mothers with normal gestational course and spontaneous delivery were selected. Blood samples were taken from mother (before and after delivery) both from vein and artery of umbilical cord. Lower antioxidant enzymes activities were observed in neonates compared with their mothers and lower oxidative stress in umbilical cord artery with respect to vein. There was an overexpression of inflammatory cytokines in the mother, such as IL-6 and TNF-α, and, in addition, PGE2 was also increased. Neonates showed lower levels of IL-6 and TNF-α and higher values of sTNF-RII and PGE2 in comparison with their mothers. Parturition increases oxidative damage in the mother, although the indicators of oxidative damage were lower in umbilical cord artery with respect to umbilical vein. The overexpression of inflammatory cytokines reveals that fetus suffers its own inflammatory process during parturition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.