Evidence map›Paper›PMID 25722756›Full record

ArticleJournal of analytical oncology2014

'Hygienic' lymphocytes convey increased cancer risk.

Tatiana Levkovich, Theofilos Poutahidis, Kelsey Cappelle, Mark B Smith, Allison Perrotta, Eric J Alm, Susan E Erdman

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of analytical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Role of the microbiome in non-gastrointestinal cancers.World journal of clinical oncology · 2016
    Review
  3. Article
  4. Gut bacteria and cancer.Biochimica et biophysica acta · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tatiana LevkovichDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139.
Theofilos PoutahidisDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 ; Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece 54124.
Kelsey CappelleDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139.
Mark B SmithBiological Engineering, Massachusetts Institute of Technology, Cambridge MA 02139 United States.
Allison PerrottaBiological Engineering, Massachusetts Institute of Technology, Cambridge MA 02139 United States.
Eric J AlmBiological Engineering, Massachusetts Institute of Technology, Cambridge MA 02139 United States ; Broad Institute of MIT and Harvard, Cambridge, MA, United States.
Susan E ErdmanDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139.
Massachusetts Institute of Technology · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
GI Tract Dysbiosis and Breast CancerU01CA164337 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E, WANG, TIMOTHY CRAGIN · 2012 to 2016
$2.6M
Role of IL10 and TGFb1 in colon cancerR01CA108854 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E · 2005 to 2014
$2.4M
NCI NIH HHS R01 CA108854NCI NIH HHS U01 CA164337NIEHS NIH HHS P30 ES002109
6 · The paper itself

Abstract

Risk of developing inflammation-associated cancers has increased in industrialized countries during the past 30 years. One possible explanation is societal hygiene practices with use of antibiotics and Caesarian births that provide too few early life exposures of beneficial microbes. Building upon a 'hygiene hypothesis' model whereby prior microbial exposures lead to beneficial changes in CD4

Indexed as

ApcMin/+cancerhygieneinflammationmicrobiome

Identifiers

PMID25722756
PMCPMC4338962
OpenAlexW2019703092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.