Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis.

Yunliang Xie, Yanbo Liu, Weigao Shen, Bo Zhang, Qun Liu

Open access · greenAbstract read

In one paragraph

Article in Neural regeneration research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 75% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Caspase-4 in glioma indicates deterioration and unfavorable prognosis by affecting tumor cell proliferation and immune cell recruitment.Scientific reports · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yunliang XieDepartment of Neurology, First Clinical Hospital of Bethune Medical College of Jilin University, Changchun 130001, Jilin Province, China ; Department of Anatomy, Basic Medical College, Beihua University, Jilin 132013, Jilin Province, China.

Yanbo LiuDepartment of Anatomy, Basic Medical College, Beihua University, Jilin 132013, Jilin Province, China.

Weigao ShenDepartment of Anatomy, Basic Medical College, Beihua University, Jilin 132013, Jilin Province, China.

Bo ZhangDepartment of Anatomy, Basic Medical College, Beihua University, Jilin 132013, Jilin Province, China.

Qun LiuDepartment of Neurology, First Clinical Hospital of Bethune Medical College of Jilin University, Changchun 130001, Jilin Province, China.

First Bethune Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibited the expression of the cell cycle regulatory proteins, survivin, cyclinD1, c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel.

Indexed as

gliomaneural regenerationpaclitaxelRNA interferencesurvivin

Identifiers

PMID25722690

DOI10.3969/j.issn.1673-5374.2012.13.008

PMCPMC4341272

OpenAlexW2408798032

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-SA

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.