Evidence map›Paper›PMID 25722650›Full record

ArticleThe Cochrane database of systematic reviews

Alternative agents versus prophylactic platelet transfusion for preventing bleeding in patients with haematological disorders after chemotherapy or stem cell transplantation.

Lise J Estcourt, Richard Gregg, Simon Stanworth, Carolyn Doree, Marialena Trivella, Michael F Murphy, Alan Tinmouth

Abstract read
In one paragraph

Article in The Cochrane database of systematic reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Lise J EstcourtHaematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.
Richard GreggDepartment of Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Simon StanworthHaematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.
Carolyn DoreeSystematic Review Initiative, NHS Blood and Transplant, Oxford, UK.
Marialena TrivellaCentre for Statistics in Medicine, University of Oxford, Oxford, UK.
Michael F MurphyNHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK.
Alan TinmouthMedicine (hematology) and Pathology Centre for Transfusion Research, The Ottawa Health Research Institute and the University of Ottawa, Ottawa, Canada.
NHS Blood and Transplant · GBJohn Radcliffe Hospital · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Oxford · GB

Funding

Cancer Research UK 16895Department of Health 13/89/09Department of Health SRP/13/89/09
6 · The paper itself

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: To determine whether alternative agents (e.g. artificial platelet substitutes, platelet-poor plasma, fibrinogen, rFVIIa, thrombopoietin mimetics) are as effective and safe as the use of platelet transfusions for the prevention of bleeding (prophylactic platelet transfusion) in patients with haematological disorders who are undergoing myelosuppressive chemotherapy or stem cell transplantation. Antifibrinolytics (lysine analogues) will not be included in this review because they have been the focus of another Cochrane review (Wardrop 2013).

Identifiers

PMID25722650
PMCPMC4338548
OpenAlexW1953960396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.