Evidence map›Paper›PMID 25722465›Full record

ReviewCold Spring Harbor perspectives in biology2015

Drosophila Central Nervous System Glia.

Marc R Freeman

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed.

  1. Article
  2. Review
  3. eLife · 2026
    Article
  4. Article
  5. Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Review
  7. Organization and evolution of sex-biased gene expression inbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Frontiers in cell and developmental biology · 2026
    Review
  11. Regulating glial morphogenesis: insights fromFrontiers in cell and developmental biology · 2026
    Review
  12. Article
  13. Review
  14. Article
  15. ALife science alliance · 2025
    Article
  16. Article
  17. Review
  18. bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Marc R FreemanDepartment of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605.

Funding

Astrocyte control of neural circuits and behaviorR37NS053538 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEMAN, MARC R · 2016 to 2022
$2.9M
Howard Hughes Medical InstituteNINDS NIH HHS R01 NS03538NINDS NIH HHS R37 NS053538
6 · The paper itself

Abstract

Molecular genetic approaches in small model organisms like Drosophila have helped to elucidate fundamental principles of neuronal cell biology. Much less is understood about glial cells, although interest in using invertebrate preparations to define their in vivo functions has increased significantly in recent years. This review focuses on our current understanding of the three major neuron-associated glial cell types found in the Drosophila central nervous system (CNS)-astrocytes, cortex glia, and ensheathing glia. Together, these cells act like mammalian astrocytes: they surround neuronal cell bodies and proximal neurites, are coupled to the vasculature, and associate closely with synapses. Exciting recent work has shown essential roles for these CNS glial cells in neural circuit formation, function, plasticity, and pathology. As we gain a more firm molecular and cellular understanding of how Drosophila CNS glial cells interact with neurons, it is becoming clear they share significant molecular and functional attributes with mammalian astrocytes.

Indexed as

Models, BiologicalAnimalsAstrocytesCell CommunicationDrosophilaNerve NetNeurogliaNeuronal PlasticityNeurons

Identifiers

PMID25722465
PMCPMC4632667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.