Evidence map›Paper›PMID 25722428›Full record

ArticleStem cells translational medicine2015

Systemically delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b+ cell-dependent mechanism.

Marvin E Morris, Jason E Beare, Robert M Reed, Jacob R Dale, Amanda J LeBlanc, Christina L Kaufman, Huaiyu Zheng, Chin K Ng, Stuart K Williams, James B Hoying

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The role of orthobiologics in chronic wound healing.International wound journal · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Stromal Vascular Fraction and its Role in the Management of Alopecia: A Review.The Journal of clinical and aesthetic dermatology · 2019
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marvin E MorrisCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
Jason E BeareCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
Robert M ReedCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
Jacob R DaleCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
Amanda J LeBlancCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
Christina L KaufmanCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
Huaiyu ZhengCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
Chin K NgCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
Stuart K WilliamsCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA.
James B HoyingCardiovascular Innovation Institute, Department of Surgery, Department of Physiology and Biophysics, and Department of Radiology, University of Louisville, Louisville, Kentucky, USA; Christina M. Kleinert Institute, Louisville, Kentucky, USA jay.hoying@louisville.edu.

Funding

NIGMS NIH HHS P30 GM13507
6 · The paper itself

Abstract

Vasoactivity, an important aspect of tissue healing, is often compromised in disease and tissue injury. Dysfunction in the smaller vasoactive arteries is most impactful, given the role of these vessels in controlling downstream tissue perfusion. The adipose stromal vascular fraction (SVF) is a mix of homeostatic cells shown to promote tissue healing. Our objective was to test the hypothesis that autologous SVF cells therapeutically modulate peripheral artery vasoactivity in syngeneic mouse models of small artery function. Analysis of vasoactivity of saphenous arteries isolated from normal mice 1 week after intravenous injection of freshly isolated SVF cells revealed that pressure-dependent artery vasomotor tone was decreased by the SVF cell isolate, but not one depleted of CD11b(+) cells. Scavenging hydrogen peroxide in the vessel wall abrogated the artery relaxation promoted by the SVF cell isolate. Consistent with a CD11b(+) cell being the relevant cell type, SVF-derived F4/80-positive macrophages were present within the adventitia of the artery wall coincident with vasorelaxation. In a model of artery inflammation mimicking a common disease condition inducing vasoactive dysfunction, the SVF cells potentiated relaxation of saphenous arteries without structurally remodeling the artery via a CD11b(+) cell-dependent manner. Our findings demonstrate that freshly isolated, adipose SVF cells promote vasomotor relaxation in vasoactive arteries via a hydrogen peroxide-dependent mechanism that required CD11b(+) cells (most likely macrophages). Given the significant impact of small artery dysfunction in disease, we predict that the intravenous delivery of this therapeutic cell preparation would significantly improve tissue perfusion, particularly in diseases with diffuse vascular involvement.

Indexed as

AdipocytesAdipose TissueAnimalsArteriesCD11b AntigenMacrophagesMiceStromal CellsVasomotor SystemCD11b AntigenITGAM protein, humanAdipose stromal vascular fractionCell therapyMacrophageSmall arteryVasomotor tone

Identifiers

PMID25722428
PMCPMC4367510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.