ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Cpeb1 remodels cell type-specific translational program to promote fear extinction.Science advances · 2025Article
- Article
- Involvement of PKMζ in Stress Response and Depression.Frontiers in cellular neuroscience · 2022Review
- Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway.Journal of neuroinflammation · 2021Article
- Memory Destabilization and Reconsolidation Dynamically Regulate the PKMζ Maintenance Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease.Journal of neuroinflammation · 2021Article
- High-Frequency Deep Brain Stimulation of the Substantia Nigra Pars Reticulata Facilitates Extinction and Prevents Reinstatement of Methamphetamine-Induced Conditioned Place Preference.Frontiers in pharmacology · 2021Article
- Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model.Frontiers in molecular neuroscience · 2019Article
- Traumatic Stress Produces Delayed Alterations of Synaptic Plasticity in Basolateral Amygdala.Frontiers in psychology · 2019Article
- Protein kinase Mζ in medial prefrontal cortex mediates depressive-like behavior and antidepressant response.Molecular psychiatry · 2018Article
- Antidiabetic and Neuroprotective Effect of the N-Butanol Extract ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Traumatic Stress Produces Distinct Activations of GABAergic and Glutamatergic Neurons in Amygdala.Frontiers in neuroscience · 2018Article
- Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors.Molecular brain · 2017Article
- Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood.Scientific reports · 2017Article
- BDNF-GSK-3β-β-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats.The international journal of neuropsychopharmacology · 2017Article
- EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Overexpression of Protein Kinase Mζ in the Hippocampus Enhances Long-Term Potentiation and Long-Term Contextual But Not Cued Fear Memory in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Epigenetic modification of PKMζ rescues aging-related cognitive impairment.Scientific reports · 2016Article
- Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory.Scientific reports · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroplasticity in the prefrontal cortex (PFC) after fear conditioning has been suggested to regulate the formation and expression of fear memory. Protein kinase Mζ (PKMζ), an isoform of protein kinase C with persistent activity, is involved in the formation and maintenance of memory. However, less is known about the role of PKMζ in the PFC in the formation of fear memory. We investigated whether the overexpression of PKMζ enhances the formation of auditory fear memory in rats. We found that microinfusion of lentiviral vector-expressing PKMζ into the prelimbic cortex (PrL) selectively enhanced the expression of PKMζ without influencing the expression of other isoforms of PKC. The overexpression of PKMζ in the PrL enhanced the formation of long-term fear memory without affecting short-term fear memory, whereas the overexpression of PKMζ in the infralimbic cortex had no effect on either short-term or long-term fear memory. The overexpression of PKMζ in the PrL had no effect on anxiety-like behavior or locomotor activity. We also found that PKMζ overexpression potentiated the fear conditioning-induced increase in the membrane levels of glutamate subunit 2 of AMPA receptors in the PrL. These results demonstrate that the overexpression of PKMζ in the PrL but not infralimbic cortex selectively enhanced the formation of long-term fear memory, and PKMζ in the PrL may be involved in the formation of fear memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.