Evidence map›Paper›PMID 25722105›Full record

ArticleVision research2015

Measurement of the photoreceptor pointing in the living chick eye.

Maria K Walker, Leonardo Blanco, Rebecca Kivlin, Stacey S Choi, Nathan Doble

Abstract read
In one paragraph

Article in Vision research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria K WalkerThe New England College of Optometry, 424 Beacon Street, Boston, MA 02115, USA. Electronic address: mariawalkerod@gmail.com.
Leonardo BlancoThe New England College of Optometry, 424 Beacon Street, Boston, MA 02115, USA. Electronic address: blanco.leonardo@gmail.com.
Rebecca KivlinThe New England College of Optometry, 424 Beacon Street, Boston, MA 02115, USA. Electronic address: rkivlin@friars.providence.edu.
Stacey S ChoiThe New England College of Optometry, 424 Beacon Street, Boston, MA 02115, USA. Electronic address: choi.1080@osu.edu.
Nathan DobleThe New England College of Optometry, 424 Beacon Street, Boston, MA 02115, USA. Electronic address: doble.2@osu.edu.

Funding

SHORT TERM RES TRAINING AT THE NEW ENGLAND COLLEGE OFT35EY007149 · NEI · NEW ENGLAND COLLEGE OF OPTOMETRY · PI Athanasios Panorgias · 1999 to 2026
$1.5M
In-vivo, High Contrast Imaging of the Human Rod Photoreceptor MosaicR01EY020901 · NEI · OHIO STATE UNIVERSITY · PI DOBLE, NATHAN · 2010 to 2013
$1.2M
NEI NIH HHS EY020901NEI NIH HHS R01 EY020901NEI NIH HHS T35 EY007149
6 · The paper itself

Abstract

The chick eye is used in the study of ocular growth and emmetropization; however optical aberrations in the lens and cornea limit the ability to visualize fine retinal structure in living eyes. These aberrations can be corrected using adaptive optics (AO) allowing for cellular level imaging in vivo. Here, this capability is extended to measure the angular tuning properties of individual photoreceptors. The left eyes from two White Leghorn chicks (Gallus gallus domesticus) labeled chick A and chick B, were imaged using an AO flood illuminated fundus camera. By translating the entrance pupil position, the same retinal location was illuminated with light of varying angles allowing for the measurement of individual photoreceptor pointing. At 30° nasal from the pecten tip, the pointing direction for both chicks was towards the pupil center with a narrow distribution. These particular chicks were found to have a temporal (T) and inferior (I) bias in the alignment with peak positions of (0.81 T, 0.23 I) and (0.57 T, 0.18 I) mm from the pupil center for chicks A and B respectively. The rho, ρ, values for the major, ρL, and minor, ρs, axes were 0.14 and 0.17mm(-2) for chick A and 0.09 and 0.20mm(-2) for chick B. The small disarray in the alignment of the chick photoreceptors implies that the photoreceptors are aligned to optimize the light entering the eye through the central portion of the pupil aperture. The ability to measure pointing properties of individual photoreceptors will have application in the study of eye growth and various retinal disorders.

Indexed as

AnimalsChickensPhotographyPhotoreceptor Cells, VertebrateRefractive ErrorsRetinaAdaptive opticsChickIn vivo retinal imagingPhotoreceptorsRetinaStiles–Crawford Effect of the First Kind

Identifiers

PMID25722105
PMCPMC4385468

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.