ArticleNeonatology2015
Ketamine Attenuates the ACTH Response to Hypoxia in Late-Gestation Ovine Fetus.
Article in Neonatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Effects of different nitric oxide synthases on pulmonary and systemic hemodynamics in hypoxic stress rat model.Animal models and experimental medicine · 2025Article
- Efficacy of intraoperative ketamine/esketamine in the prevention of postoperative delirium: a systematic review and meta-analysis.Therapeutic advances in psychopharmacology · 2025Article
- Fetal cardiovascular response to acute hypoxia during maternal anesthesia.Physiological reports · 2020Article
- Current paradigms and new perspectives on fetal hypoxia: implications for fetal brain development in late gestation.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- Effects of ketamine on the fetal transcriptomic response to umbilical cord occlusion: comparison with hypoxic hypoxia in the cerebral cortex.The Journal of physiology · 2018Article
- Ketamine Reduces Inflammation Pathways in the Hypothalamus and Hippocampus Following Transient Hypoxia in the Late-Gestation Fetal Sheep.Frontiers in physiology · 2018Article
- Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus.Scientific reports · 2017Article
- Ketamine modulates fetal hemodynamic and endocrine responses to umbilical cord occlusion.Physiological reports · 2016Article
- Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex.The Journal of physiology · 2016Article
- Ketamine decreases inflammatory and immune pathways after transient hypoxia in late gestation fetal cerebral cortex.Physiological reports · 2016Article
- Transcriptomics Modeling of the Late-Gestation Fetal Pituitary Response to Transient Hypoxia.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundKetamine, a noncompetitive N-Methyl-D-aspartate (NMDA) receptor antagonist, is a commonly used dissociative anesthetic in neonatology. We have proposed that ketamine reduces fetal stress responsiveness to stimuli that involve reduced oxygen supply to the fetal brain. Previously, we have shown that ketamine inhibits plasma ACTH levels in late-gestation fetal sheep subjected to brachiocephalic artery occlusion (BCO), an ischemic hypoxia model that might activate some of the same direct and reflex responses as hypoxia.
objectivesWe performed the current study to test the hypothesis that ketamine pretreatment will reduce fetal ACTH responses to hypoxic hypoxia (HH).
methodsFetal sheep were chronically catheterized at least 5 days prior to study. Ketamine (3 mg/kg) was administered intravenously to the fetus 10 min prior to normoxia or a period of hypoxia induced by administration of nitrogen gas to the maternal trachea for 30 min.
resultsHypoxia significantly increased both fetal ACTH and cortisol levels in both the control and ketamine groups (p < 0.0005, interaction effect of time·stimulus in two-way ANOVA), and the ACTH response was blunted by ketamine (p < 0.005).
conclusionsKetamine reduced fetal ACTH responses to HH, possibly due to antagonism of the NMDA receptors in the fetal brain. Interestingly, in contrast to the responses to BCO, ACTH responses to HH were only partially inhibited, suggesting that multiple neurotransmitter pathways mediate the ACTH response to HH.
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