SynthesisEpidemiology and infection2015
Case-fatality of hand, foot and mouth disease associated with EV71: a systematic review and meta-analysis.
Synthesis in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Estimating case fatality risk of severe Yellow Fever cases: systematic literature review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Risk factors for death from hand-foot-mouth disease: a meta-analysis.Epidemiology and infection · 2020Pooled it
- Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2018Pooled it
- The Epidemiology of Hand, Foot and Mouth Disease in Asia: A Systematic Review and Analysis.The Pediatric infectious disease journal · 2016Pooled it
- Estimating the Severity Profile of Enterovirus A71 Infections in Children: A Bayesian Synthesis Framework.American journal of epidemiology · 2019Trial
- Clinical characteristics of fatal cases of hand, foot and mouth disease in children.Frontiers in pediatrics · 2025Article
- Clinical Potential of Misshapen/NIKs-Related Kinase (MINK) 1-A Many-Sided Element of Cell Physiology and Pathology.Current issues in molecular biology · 2024Review
- Chinese parents' intention to vaccinate their 0-5-year-old children with the EV-71 vaccine against hand, foot, and mouth disease and willingness-to-pay.Frontiers in public health · 2024Article
- The secular trend of enterovirus A71 after the implementation of preventive measures in Taiwan.BMC public health · 2022Article
- Early warning of hand, foot, and mouth disease transmission: A modeling study in mainland, China.PLoS neglected tropical diseases · 2021Article
- Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013-2015: Inpatients and outpatients.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019Observational
- Reinfection hazard of hand-foot-mouth disease in Wuhan, China, using Cox-proportional hazard model.Epidemiology and infection · 2018Article
- Severity and burden of hand, foot and mouth disease in Asia: a modelling study.BMJ global health · 2018Article
- Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand, foot and mouth disease (HFMD) associated with enterovirus 71 (EV71) is a growing public health concern. This study aimed to estimate the case-fatality of HFMD associated with EV71 on the basis of a meta-analysis. We searched PubMed, Cochrane, Web of Science, Elsevier, CNKI, Wanfang, and VIP databases. Two authors independently selected relevant studies. The pooled estimate of case-fatality was calculated using a random-effects model. Potential sources of heterogeneity were explored using subgroup analysis, sensitivity analysis and meta-regression. We identified 14 eligible studies with a total population of 112 546. The random-effects pooled case-fatality was 1·7% (95% confidence interval 1·2-2·4). The funnel plot was asymmetrical. The estimate of case-fatality was highest in mainland China (1·8%). Removal of eight local Chinese studies decreased the original estimate. The pooled case-fatality in the period of 1998-2007 (1·5%) was lower than that in the period 2008-2012 (1·8%). Control measures for HFMD associated with EV71 are essential because of the increased case-fatality over time, especially in East Asia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.