Evidence map›Paper›PMID 25721296›Full record

ArticleMedical image analysis2015

Patient-specific biomechanical model as whole-body CT image registration tool.

Mao Li, Karol Miller, Grand Roman Joldes, Barry Doyle, Revanth Reddy Garlapati, Ron Kikinis, Adam Wittek

Open access · greenAbstract read
In one paragraph

Article in Medical image analysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
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  4. Computer simulation of tumour resection-induced brain deformation by a meshless approach.International journal for numerical methods in biomedical engineering · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Biomechanical model for computing deformations for whole-body image registration: A meshless approach.International journal for numerical methods in biomedical engineering · 2016
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Mao LiIntelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, Perth, Australia.
Karol MillerIntelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, Perth, Australia; Institute of Mechanics and Advanced Materials, Cardiff School of Engineering, Cardiff University, Cardiff, Wales, UK.
Grand Roman JoldesIntelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, Perth, Australia.
Barry DoyleVascular Engineering, Intelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, Perth, Australia; Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK.
Revanth Reddy GarlapatiIntelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, Perth, Australia.
Ron KikinisSurgical Planning Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Fraunhofer MEVIS, Bremen, Germany; Professor für Medical Image Computing, MZH, University of Bremen, Bremen, Germany.
Adam WittekIntelligent Systems for Medicine Laboratory, School of Mechanical and Chemical Engineering, The University of Western Australia, Crawley, Perth, Australia. Electronic address: adam.wittek@uwa.edu.au.
University of Western Australia · AUBrigham and Women's Hospital · USUniversity of Edinburgh · GB

Funding

Washington University ConsoritumU54EB005149 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON · 2004 to 2013
$39.3M
WHITE MATTER ARCHITECTURE FROM DT-MRIP41RR013218 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON · 1998 to 2011
$30.6M
Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI PUJOL, SONIA · 2012 to 2022
$20.9M
Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patientsP41EB015898 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2012 to 2021
$18.9M
ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULLU41RR019703 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2005 to 2009
$17.2M
Quantitative Image Informatics for Cancer Research (QIICR)U24CA180918 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEDOROV, ANDRIY, KIKINIS, RON · 2013 to 2017
$4.0M
Assessment of Improved Navigation for Pediatric Brain Tumor SurgeryR01EB008015 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2007 to 2010
$1.6M
Informatics Algorithms for Neural Circuitry UltrastructureR01LM010033 · NLM · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2010 to 2012
$1.3M
NCI NIH HHS U24 CA180918NCI NIH HHS U24CA180918NCRR NIH HHS P41 RR013218NCRR NIH HHS U41 RR019703NCRR NIH HHS U41RR019703NIBIB NIH HHS P41 EB015898NIBIB NIH HHS P41EB015898NIBIB NIH HHS P41 EB015902NIBIB NIH HHS P41EB015902NIBIB NIH HHS R01 EB008015NIBIB NIH HHS U54 EB005149NIBIB NIH HHS U54EB005149NLM NIH HHS R01 LM010033
6 · The paper itself

Abstract

Whole-body computed tomography (CT) image registration is important for cancer diagnosis, therapy planning and treatment. Such registration requires accounting for large differences between source and target images caused by deformations of soft organs/tissues and articulated motion of skeletal structures. The registration algorithms relying solely on image processing methods exhibit deficiencies in accounting for such deformations and motion. We propose to predict the deformations and movements of body organs/tissues and skeletal structures for whole-body CT image registration using patient-specific non-linear biomechanical modelling. Unlike the conventional biomechanical modelling, our approach for building the biomechanical models does not require time-consuming segmentation of CT scans to divide the whole body into non-overlapping constituents with different material properties. Instead, a Fuzzy C-Means (FCM) algorithm is used for tissue classification to assign the constitutive properties automatically at integration points of the computation grid. We use only very simple segmentation of the spine when determining vertebrae displacements to define loading for biomechanical models. We demonstrate the feasibility and accuracy of our approach on CT images of seven patients suffering from cancer and aortic disease. The results confirm that accurate whole-body CT image registration can be achieved using a patient-specific non-linear biomechanical model constructed without time-consuming segmentation of the whole-body images.

Indexed as

SoftwareSubtraction TechniqueAlgorithmsFeasibility StudiesFinite Element AnalysisFuzzy LogicHumansImaging, Three-DimensionalPatient-Specific ModelingPattern Recognition, AutomatedRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSensitivity and SpecificityTomography, X-Ray ComputedWhole Body ImagingFuzzy-C MeansHausdorff distanceNon-linear finite element analysisPatient-specific biomechanical modelWhole-body image registration

Identifiers

PMID25721296
PMCPMC4405489
OpenAlexW1977863614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.