Evidence map›Paper›PMID 25721210›Full record

ArticleCancer gene therapy2015

Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer.

Z Zhang, J Huang, C Zhang, H Yang, H Qiu, J Li, Y Liu, L Qin, L Wang, S Hao and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cancer gene therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Tumor-infiltrating CD45ROScientific reports · 2017
    Pooled it
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  3. Loss ofOncotarget · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Z ZhangDepartment of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
J Huang1] Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China [2] Department of Gynecology and Obstetrics, NO.3 People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201900, China.
C ZhangResearch Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
H YangDepartment of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
H QiuDepartment of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
J LiDepartment of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Y LiuDepartment of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
L QinDepartment of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
L WangDepartment of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
S HaoDepartment of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
F ZhangDepartment of General Surgery, Hebei General Hospital, Shijiazhuang, China.
X WangDepartment of pathology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
B ShanResearch Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Hebei Medical University · CNFourth Hospital of Hebei Medical University · CNHebei General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to analyze the association between the distribution of dendritic cells (DC) with expression of tumor-infiltrating T lymphocytes and clinicopathologic parameters with prognosis in epithelial ovarian cancer (EOC). Thirty-three EOC patient samples were surgically resected, and pathology was examined for clinicopathological variables. Expression of S-100, CD1a, CD45RA and CD45RO was detected using the avidin-biotin complex immunohistochemical technique. The correlation of protein expression with surgical and pathological stage, histological grade, pathological type and prognosis was analyzed. There was significant difference in the CD45RA positive rate in early- and advanced-stage EOC with 50 and 10.5%, respectively (P<0.05). Univariate analysis showed that CD45RO, histological grade and surgical-pathological staging were all factors that influenced the prognosis of patients with EOC. Higher survival rates were found in patients with harboring populations of CD1a(+) DC and CD45RO(+) T lymphocytes or populations of S-100(+) DC and CD45RO(+) T lymphocytes (P<0.05). In addition, histological grade is related to cumulative survival rate. The higher degree of cell differentiation presented better outcome. In conclusion, EOC patients with populations of DC and CD45RO(+) T lymphocytes had a higher survival rate. Histological grade and surgical-pathological stage were independent factors affecting prognosis.

Indexed as

AdultAgedAntigens, CD1Carcinoma, Ovarian EpithelialDendritic CellsHumansKaplan-Meier EstimateLymphocytes, Tumor-InfiltratingMiddle AgedMultivariate AnalysisNeoplasms, Glandular and EpithelialOvarian NeoplasmsProportional Hazards ModelsS100 ProteinsT-LymphocytesTreatment OutcomeAntigens, CD1CD1a antigenS100 Proteins

Identifiers

PMID25721210
OpenAlexW2015974753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.