Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2015
Predictors associated with improved cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What Is the Added Benefit of Combining Cognitive Behavioral Therapy and Selective Serotonin Reuptake Inhibitors in Youth with Obsessive Compulsive Disorder? A Bayesian Hierarchical Modeling Meta-Analysis.Journal of child and adolescent psychopharmacology · 2023Pooled it
- Moderators of Response to Personalized and Standard Care Cognitive-Behavioral Therapy for Youth with Autism Spectrum Disorder and Comorbid Anxiety.Journal of autism and developmental disorders · 2022Trial
- Sudden gains in cognitive behavioral therapy among children and adolescents with obsessive compulsive disorder.Journal of behavior therapy and experimental psychiatry · 2019Trial
- Improvement in anxiety and depression symptoms following cognitive behavior therapy for pediatric obsessive compulsive disorder.Psychiatry research · 2019Trial
- D-Cycloserine augmentation of cognitive behavior therapy for pediatric OCD: Predictors and moderators of outcome.Journal of affective disorders · 2018Trial
- Quality of Life in Children and Youth with Obsessive-Compulsive Disorder.Journal of child and adolescent psychopharmacology · 2018Trial
- Prediction of outcome in internet-delivered cognitive behaviour therapy for paediatric obsessive-compulsive disorder: A machine learning approach.International journal of methods in psychiatric research · 2018Trial
- Glutamate in Pediatric Obsessive-Compulsive Disorder and Response to Cognitive-Behavioral Therapy: Randomized Clinical Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy.Journal of child and adolescent psychopharmacology · 2015Trial
- Cognitive and emotional traits as mediators in the relationship between family factors and obsessive-compulsive disorder in adolescents.BMC psychiatry · 2026Article
- Using latent patient-centered fear extinction profiles to guide treatment in pediatric OCD.Psychiatry research · 2025Article
- Stepped Care Versus Stratified Care for Youth with Anxiety Disorders: a Pilot Randomized Controlled Trial.Child psychiatry and human development · 2025Article
- Family Accommodation in Pediatric Obsessive-Compulsive Disorder: Investigating Prevalence and Clinical Correlates in the NordLOTS Study.Child psychiatry and human development · 2025Article
- Longitudinal and cross-sectional predictors of sleep disturbance in a treatment follow-up sample with Tourette's disorder.Frontiers in psychiatry · 2025Article
- Insomnia as a predictor of treatment outcomes in adolescents receiving concentrated exposure treatment for OCD.BMC psychiatry · 2024Article
- Specific Contamination Symptoms are Associated with Experiencing a Limited Response of Cognitive-Behavioral Therapy in Pediatric Patients with OCD.Child psychiatry and human development · 2024Article
- The effectiveness and acceptability of the Bergen 4-day treatment for adolescents with OCD: a replication and extension.BMC psychiatry · 2024Article
- Functional impairment in a Spanish Sample of Children and Adolescents with Obsessive-Compulsive Disorder.Child psychiatry and human development · 2024Article
- Do Autistic Traits Predict Outcome of Cognitive Behavioral Therapy in Pediatric Obsessive-Compulsive Disorder?Research on child and adolescent psychopathology · 2023Article
- Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods.Psychiatry research communications · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify predictors of treatment response in a large sample of pediatric participants with obsessive-compulsive disorder (OCD). The Nordic Long-term Obsessive compulsive disorder (OCD) Treatment Study (NordLOTS) included 269 children and adolescents, 7 to 17 years of age, with a DSM-IV diagnosis of OCD. Outcomes were evaluated after 14 weekly sessions of exposure-based cognitive-behavioral therapy (CBT).
methodThe association of 20 potential predictors, identified by literature review, along with their outcomes, was evaluated using the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) posttreatment. A CY-BOCS total score of ≤15 was the primary outcome measure.
resultsThe univariate analyses showed that children and adolescents who were older had more severe OCD, greater functional impairment, higher rates of internalizing and externalizing symptoms, and higher levels of anxiety and depression symptoms before treatment had significantly poorer outcomes after 14 weeks of treatment. However, only age was a significant predictor in the multivariate model.
conclusionIn the multivariate analysis, only age predicted better treatment outcome. Using univariate analysis, a variety of predictors of poorer treatment outcome after CBT was identified. The high impact of comorbid symptoms on outcome in pediatric OCD suggests that treatment should address comorbidity issues. The lack of a family predictor may be related to high family involvement in this study. Future research strategies should focus on optimizing intervention in the presence of these characteristics to achieve greater benefits for patients with OCD. Clinical trial registration information-Nordic Long-term Obsessive compulsive disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.