ArticleG3 (Bethesda, Md.)2015
A Multipurpose, High-Throughput Single-Nucleotide Polymorphism Chip for the Dengue and Yellow Fever Mosquito, Aedes aegypti.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Introgression Shapes Genetic Variation Associated With Humid Environments in Aedes aegypti Mosquitoes From Saudi Arabia.Molecular ecology · 2026Article
- A targeted amplicon sequencing panel for cost-effective high-throughput genotyping of Aedes aegypti.Parasites & vectors · 2026Article
- Genomic prediction in insects: a case study on wing morphology traits in the jewel wasp Nasonia vitripennis.G3 (Bethesda, Md.) · 2026Article
- Investigating genetic differentiation between brackish and fresh water collections of the arboviral vector Aedes aegypti.Parasites & vectors · 2026Article
- A targeted amplicon sequencing panel for cost-effective high-throughput genotyping ofbioRxiv : the preprint server for biology · 2025Article
- Population genetic analysis of Aedes aegypti reveals evidence of emerging admixture populations in coastal Kenya.PLoS neglected tropical diseases · 2025Article
- Population Structure of the Invasive Asian Tiger Mosquito,Ecology and evolution · 2025Article
- Evolutionary adaptation under climate change:Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The application of DNA markers in population genetics of mosquitoes: a comprehensive review.Frontiers in insect science · 2025Review
- Identification of Single Nucleotide Polymorphism from Insect Genomic Data.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Genomic Analysis ofVector borne and zoonotic diseases (Larchmont, N.Y.) · 2024Article
- Evaluation of Aedes aegypti control intervention with pyriproxyfen by lcWGS in Manacapuru, Amazonas, Brazil.PLoS neglected tropical diseases · 2024Article
- Evolutionary adaptation under climate change:bioRxiv : the preprint server for biology · 2024Article
- Article
- Robustness in population-structure and demographic-inference results derived from the Aedes aegypti genotyping chip and whole-genome sequencing data.G3 (Bethesda, Md.) · 2024Article
- A genotyping array for the globally invasive vector mosquito, Aedes albopictus.Parasites & vectors · 2024Article
- Strong Positive Selection in Aedes aegypti and the Rapid Evolution of Insecticide Resistance.Molecular biology and evolution · 2023Article
- Evidence for serial founder events during the colonization of North America by the yellow fever mosquito,Ecology and evolution · 2022Article
- Novel and Broadly Applicable Microsatellite Markers in Identified Chromosomes of the Philippine Dengue Mosquitoes, Aedes aegypti (Diptera: Culicidae).Journal of medical entomology · 2022Article
- An alien in Marseille: investigations on a single Aedes aegypti mosquito likely introduced by a merchant ship from tropical Africa to Europe.Parasite (Paris, France) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The dengue and yellow fever mosquito, Aedes aegypti, contributes significantly to global disease burden. Genetic study of Aedes aegypti is essential to understanding its evolutionary history, competence as a disease vector, and the effects and efficacy of vector control methods. The prevalence of repeats and transposable elements in the Aedes aegypti genome complicates marker development and makes genome-wide genetic study challenging. To overcome these challenges, we developed a high-throughput genotyping chip, Axiom_aegypti1. This chip screens for 50,000 single-nucleotide polymorphisms present in Aedes aegypti populations from around the world. The array currently used genotypes 96 samples simultaneously. To ensure that these markers satisfy assumptions commonly made in many genetic analyses, we tested for Mendelian inheritance and linkage disequilibrium in laboratory crosses and a wild population, respectively. We have validated more than 25,000 of these markers to date, and expect this number to increase with more sampling. We also present evidence of the chip's efficacy in distinguishing populations throughout the world. The markers on this chip are ideal for applications ranging from population genetics to genome-wide association studies. This tool makes rapid, cost-effective, and comparable genotype data attainable to diverse sets of Aedes aegypti researchers, from those interested in potential range shifts due to climate change to those characterizing the genetic underpinnings of its competence to transmit disease.
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