ArticleScientific reports2015
Regulation of primary metabolic pathways in oyster mushroom mycelia induced by blue light stimulation: accumulation of shikimic acid.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 41 citations in OpenAlex.
- Blue-Light Exposure Enhances Productivity, Total Phenolic Content, and Sensory Attributes in Edible Mushrooms: A Multispecies Study.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Article
- Alkyl shikimates promote proliferation of human dermal fibroblasts and exhibit structure-activity relationships.Scientific reports · 2026Article
- Comparative proteomic analysis reveals the effects of different light spectra on protein expression inFrontiers in fungal biology · 2026Article
- Article
- Transcriptomic and metabolomic insights into flavor variations in wild and cultivated Agaricus bisporus.Scientific reports · 2025Article
- Influence of low-intensity artificial light on the fatty acid profile of the biotechnologically important culinary mushroom Pleurotus eryngii in vitro.BMC biotechnology · 2025Article
- Filamentous fungi as emerging cell factories for the production of aromatic compounds.Fungal biology and biotechnology · 2024Review
- Effects of Light on the Fruiting Body Color and Differentially Expressed Genes inJournal of fungi (Basel, Switzerland) · 2024Article
- Integrated transcriptome and metabolome analysis provides insights into blue light response of Flammulina filiformis.AMB Express · 2024Article
- Changes in the Histology of Walnut (International journal of molecular sciences · 2023Article
- Effect of drainage ratio during strawberry cultivation:The volatilomics-based shelf-life indicators for strawberry fruit.Frontiers in plant science · 2023Article
- Blue Light-Dependent Pre-mRNA Splicing Controls Pigment Biosynthesis in the MushroomMicrobiology spectrum · 2022Article
- Identification of Key Regulatory Pathways of Basidiocarp Formation inJournal of fungi (Basel, Switzerland) · 2022Article
- Light Irradiation Coupled with Exogenous Metal Ions to Enhance Exopolysaccharide Synthesis fromJournal of fungi (Basel, Switzerland) · 2021Article
- Transcriptomic profiling sheds light on the blue-light and red-light response of oyster mushroom (Pleurotus ostreatus).AMB Express · 2020Article
- Metabolomics differences between silkworms (Bombyx mori) reared on fresh mulberry (Morus) leaves or artificial diets.Scientific reports · 2017Article
- Water Deficit Affects Primary Metabolism Differently in Two Lolium multiflorum/Festuca arundinacea Introgression Forms with a Distinct Capacity for Photosynthesis and Membrane Regeneration.Frontiers in plant science · 2016Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Shikimic acid is a key intermediate in the aromatic amino acid pathway as well as an important starting material for the synthesis of Tamiflu, a potent and selective inhibitor of the neuraminidase enzyme of influenza viruses A and B. Here we report that in oyster mushroom (Pleurotus ostreatus) mycelia cultivated in the dark, stimulation with blue light-emitting diodes induces the accumulation of shikimic acid. An integrated analysis of primary metabolites, gene expression and protein expression suggests that the accumulation of shikimic acid caused by blue light stimulation is due to an increase in 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase (DAHPS, EC2.5.1.54), the rate-determining enzyme in the shikimic acid pathway, as well as phosphofructokinase (PFK, EC2.7.1.11) and glucose-6-phosphate dehydrogenase (G6PD, EC1.1.1.49), the rate-determining enzymes in the glycolysis and pentose phosphate pathways, respectively. This stimulation results in increased levels of phosphoenolpyruvic acid (PEP) and erythrose-4-phosphate (E4P), the starting materials of shikimic acid biosynthesis.
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