SynthesisBritish dental journal2015
Impact of haematologic deficiencies on recurrent aphthous ulceration: a meta-analysis.
Synthesis in British dental journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Serum level of vitamin D in patients with recurrent aphthous stomatitis: A systematic review and meta-analysis of case control studies.Clinical and experimental dental research · 2024Pooled it
- Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis.Frontiers in nutrition · 2023Pooled it
- Neutropenic Tonsillar Ulcer as the Initial Presentation of Acute Myeloid Leukemia in a Young Woman: A Case Report.Cureus · 2026Article
- Recurrent aphthous stomatitis information on TikTok: satisfactory or substandard?Irish journal of medical science · 2025Article
- Associations of single and multiple vitamin levels with pediatric oral mucosal diseases: a cross-sectional study with multi-model analysis.Frontiers in nutrition · 2025Article
- Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study.The Journal of international medical research · 2021Article
- Vitamin D and hematinic deficiencies in patients with recurrent aphthous stomatitis.Clinical oral investigations · 2020Article
- Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.Nature communications · 2019Article
- Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration.British dental journal · 2018Article
- Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice.Cancer medicine · 2016Review
- Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis.Caspian journal of internal medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrent aphthous ulceration (RAU) is one of the most common oral mucosal diseases, some of which may be secondary to haematologic deficiencies. This meta-analysis aims to evaluate the association between haematologic deficiencies and RAU. MATERIALS AND
methodsCase control studies were identified using a predefined search strategy that compared the difference in haematologic deficiencies between a RAU group and a control group. A meta-analysis was performed to estimate the combined odds ratios (ORs) and 95% confidence intervals (95% CIs) in a fixed-effects model and a random-effects model, as appropriate.
resultsIn this meta-analysis, nine case control studies, including total 710 cases in RAU groups and 602 cases in control groups, were considered eligible for inclusion. Overall, the combined results based on all studies showed that the rate of haematinic deficiencies was significantly high in the RAU group (vitamin B12: OR=3.75, 95% CI: 2.38-5.94; folic acid: OR=7.55, 95% CI: 3.91-14.60; ferritin: OR=2.62, 95% CI: 1.69-4.06; and haemoglobin: OR=1.77, 95% CI: 1.12-2.80).
conclusionThis meta-analysis suggests that haematologic deficiencies could be a significant risk factor for RAU. Thus, screening and treating any haematologic deficiencies may play an important role in preventing the occurrence of RAU.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.