ReviewJournal of the American College of Cardiology2015
Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders.
Review in Journal of the American College of Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility: A systematic review and meta-analysis.Anatolian journal of cardiology · 2018Pooled it
- Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.Circulation research · 2017Pooled it
- Gene regulatory network analysis identifies auranofin as an anti-atherosclerotic drug.Nature communications · 2026Article
- L-NAME promotes foam cell formation and synthetic phenotype marker changes in vascular smooth muscle cells independent of hemodynamic effects.BMC molecular and cell biology · 2026Article
- A macrophage gene-regulatory network linked to clinical severity of coronary artery disease : The STARNET and NGS-PREDICT primary blood macrophage studies.Basic research in cardiology · 2025Article
- Myocardial ischemia in nonobstructive coronary arteries: A review of diagnostic dilemmas, current perspectives, and emerging therapeutic innovations.World journal of cardiology · 2025Review
- Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis.Nature cardiovascular research · 2025Article
- Smoking-Associated Changes in Gene Expression in Coronary Artery Disease Patients Using Matched Samples.Current issues in molecular biology · 2024Article
- Associations of genetic variation and mRNA expression of PDGF/PDGFRB pathway genes with coronary artery disease in the Chinese population.Journal of cellular and molecular medicine · 2024Article
- Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia.Nature cardiovascular research · 2024Article
- Identifying a gene-regulatory network that drives fibromuscular dysplasia.Nature cardiovascular research · 2024Article
- Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome.Nature communications · 2024Article
- A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.Circulation research · 2024Article
- Causal relationship between atrial fibrillation and leukocyte telomere length: A two sample, bidirectional Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Identification of common signature genes and pathways underlying the pathogenesis association between nonalcoholic fatty liver disease and atherosclerosis.Frontiers in cardiovascular medicine · 2023Article
- The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1.PLoS genetics · 2022Article
- Atherosclerosis: Recent developments.Cell · 2022Review
- The why and how of adaptive immune responses in ischemic cardiovascular disease.Nature cardiovascular research · 2022Article
- Integrative Prioritization of Causal Genes for Coronary Artery Disease.Circulation. Genomic and precision medicine · 2022Article
- Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia.Cardiovascular research · 2022Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Genome-wide association studies (GWAS) have been extensively used to study common complex diseases such as coronary artery disease (CAD), revealing 153 suggestive CAD loci, of which at least 46 have been validated as having genome-wide significance. However, these loci collectively explain <10% of the genetic variance in CAD. Thus, we must address the key question of what factors constitute the remaining 90% of CAD heritability. We review possible limitations of GWAS, and contextually consider some candidate CAD loci identified by this method. Looking ahead, we propose systems genetics as a complementary approach to unlocking the CAD heritability and etiology. Systems genetics builds network models of relevant molecular processes by combining genetic and genomic datasets to ultimately identify key "drivers" of disease. By leveraging systems-based genetic approaches, we can help reveal the full genetic basis of common complex disorders, enabling novel diagnostic and therapeutic opportunities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.